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Merck
CN

G5044

Sigma-Aldrich

GR 32191B

≥98% (HPLC), solid

Synonym(s):

(4Z)-7-[(1R,2R,3S,5S)-5-([1,1′-Biphenyl]-4-ylmethoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C30H40NO4Cl
CAS Number:
87248-13-3
Molecular Weight:
514.10
MDL number:
MFCD04113055
UNSPSC Code:
12352200
PubChem Substance ID:
329799744
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

off-white

mp

127-128 °C

solubility

H2O: ~16 mg/mL

originator

GlaxoSmithKline

shipped in

wet ice

storage temp.

−20°C

SMILES string

Cl.O[C@H]1C[C@H](OCc2ccc(cc2)-c3ccccc3)[C@H](CC\C=C/CCC(O)=O)[C@H]1N4CCCCC4

InChI

1S/C30H39NO4.ClH/c32-27-21-28(35-22-23-15-17-25(18-16-23)24-11-5-3-6-12-24)26(13-7-1-2-8-14-29(33)34)30(27)31-19-9-4-10-20-31;/h1-3,5-6,11-12,15-18,26-28,30,32H,4,7-10,13-14,19-22H2,(H,33,34);1H/b2-1-;/t26-,27-,28-,30+;/m0./s1

InChI key

ZYOBZRTZRQKKNC-UGNABIHOSA-N

Biochem/physiol Actions

Selective TP prostanoid receptor antagonist. Inhibits U-46619-induced contraction of guinea pig trachea with IC50=1.8 nM.

Features and Benefits

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Manufactured and sold under agreement from Glaxo­Smith­Kline

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000023654
0000018782
113K4708

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