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G5131

Guanosine 5′-diphospho-D-mannose sodium salt from Saccharomyces cerevisiae

Name: Guanosine 5′-diphospho-<SC>D</SC>-mannose sodium salt from <I>Saccharomyces cerevisiae</I>
Brand: SIGMA

Type I, ≥97% (HPLC)

Synonym(s):

GDP-Man, GDP-mannose

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About This Item

Linear Formula:

C₁₆H₂₃N₅O₁₆P₂Na₂

CAS Number:

103301-73-1

Molecular Weight:

649.30

MDL number:

MFCD00070120

UNSPSC Code:

41106305

PubChem Substance ID:

24895196

NACRES:

NA.51

Assay:

≥97% (HPLC)

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type

Type I

Quality Level

200

assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)c2ncn(C3OC(COP(O)(=O)OP(O)(=O)OC4OC(CO)C(O)C(O)C4O)C(O)C3O)c2N1

InChI

1S/C16H25N5O16P2.Na.H/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15;;/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28);;

InChI key

MEXITZOHWLXZKR-UHFFFAOYSA-N

General description

Guanosine 5′-diphospho-D-mannose (GDP-D-mannose) is present in high cytosolic levels in Saccharomyces cerevisiae. It is crucial for protein mannosylation. GDP-D-mannose is an important precursor to produce GDP-l-fucose.

Application

Guanosine 5′-diphospho-D-mannose sodium salt has been used as a component of ATP regeneration system for in vitro vesicle formation from Saccharomyces cerevisiae microsomes. It has also been used as a component of the buffer for mannosyl transferase activity assay.

Guanosine 5′-diphospho-D-mannose sodium salt from Saccharomyces cerevisiae has been used as a nucleotide sugar in transglycosylation enzymatic assay and hydrolysis based catalytic reactions with S-glycosyltransferases (SunS).

Biochem/physiol Actions

Guanosine diphosphate mannose (GDP-mannose) is a nucleotide sugar substrate for glycosyltransferase (mannosylation) reactions mediated by mannosyltransferases.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品

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Direct investigation of the Aspergillus GDP-mannose transporter by STD NMR spectroscopy.

Andrea Maggioni et al.

Chembiochem : a European journal of chemical biology, 12(16), 2421-2425 (2011-09-29)

Two KTR Mannosyltransferases Are Responsible for the Biosynthesis of Cell Wall Mannans and Control Polarized Growth in Aspergillus fumigatus

Henry C, et al.

mBio, 10(1), e02647-e02618 (2019)

Ascorbate biosynthesis and function in photoprotection.

N Smirnoff

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 355(1402), 1455-1464 (2000-12-29)

Ascorbate (vitamin C) can reach very high concentrations in chloroplasts (20-300 mM). The pool size in leaves and chloroplasts increases during acclimation to high light intensity and the highest concentrations recorded are in high alpine plants. Multiple functions for ascorbate

Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major.

Daniel C Turnock et al.

Eukaryotic cell, 6(8), 1450-1463 (2007-06-15)

The cell surface glycoconjugates of trypanosomatid parasites are intimately involved in parasite survival, infectivity, and virulence in their insect vectors and mammalian hosts. Although there is a considerable body of work describing their structure, biosynthesis, and function, little is known

The coronary club.

M M Gilliland

Supervisor nurse, 10(3), 50-51 (1979-03-01)

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Global Trade Item Number

SKU	GTIN
G5131-100MG	04061833007273
G5131-10MG	04061833633076
G5131-50MG	04061833007297

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