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Merck
CN

G5146

D-(+)-Glucose

Hybri-Max™, powder, BioReagent, suitable for hybridoma

Synonym(s):

Dextrose

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About This Item

Empirical Formula (Hill Notation):
C6H12O6
CAS Number:
50-99-7
Molecular Weight:
180.16
PubChem Substance ID:
24895199
UNSPSC Code:
12352201
MDL number:
MFCD00063774
NACRES:
NA.75
EC Number:
200-075-1
Beilstein/REAXYS Number:
1724615

Key Documents

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Product Name

D-(+)-Glucose, Hybri-Max™, powder, BioReagent, suitable for hybridoma

InChI key

WQZGKKKJIJFFOK-DVKNGEFBSA-N

InChI

1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1

SMILES string

OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O

biological source

maize

grade

Hybri-Max™

product line

BioReagent

assay

≥99.5%

form

powder

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

mp

150-152 °C (lit.)

solubility

H2O: 2g + 15 mL (Tested)

Quality Level

200

Gene Information

human ... PYGM(5837)

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Application

D-(+)-Glucose has been used in cell engineering. It has also been used to perform oral glucose tolerance test.

Biochem/physiol Actions

Glycogen phosphorylase, muscle associated (PYGM), is an important contributor to glycogenolysis. Down regulation of PYGM gene is observed in schizophrenia. Mutation in PYGM leads to McArdle disease, a glycogen storage disorder. The PYGM gene is significantly associated with energy production.

General description

Glycogen phosphorylase (PYG) exists as brain and muscle isoform. It is expressed in astrocytes and neurons respectively. The PYGM gene is mapped to human chromosome 11q13.1.

Preparation Note

The material may produce a yellowish solution if prepared at a higher concentration than 2g + 15ml.

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Storage Class

11 - Combustible Solids

wgk

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000504836
0000504833
0000504833
0000504836
0000510849

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The glial phosphorylase of glycogen isoform is reduced in the dorsolateral prefrontal cortex in chronic schizophrenia
Pinacho R, et al.
Schizophrenia Research, 177(1-3), 37-43 (2016)
Novel variant in the PYGM gene causing late-onset limb-girdle myopathy, ptosis, and camptocormia
Cheraud C, et al.
Muscle and Nerve, 57(1), 157-160 (2018)
Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome
Maltese PE, et al.
Genetics and molecular research : GMR, 15(3), 1-10 (2016)
Comparative metabolic analysis of CHO cell clones obtained through cell engineering, for IgG productivity, growth and cell longevity
Wilkens CA and Gerdtzen ZP
PLoS ONE, 10(3) (2015)
Electrical vs manual acupuncture stimulation in a rat model of polycystic ovary syndrome: different effects on muscle and fat tissue insulin signaling
Johansson J, et al.
PLoS ONE, 8(1) (2013)
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Articles

Aerobic Glycolysis and the Warburg Effect

Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.

需氧糖酵解和瓦博格效应

本页面介绍了一篇有关瓦博格效应的文章，以及其如何能够在正常氧气水平下，增强肿瘤细胞中葡萄糖向乳酸的转化。Otto Heinrich Warburg在1924年证明，癌细胞显示出对糖酵解的依赖性增加，以满足他们的能量需求，无论是否有充足的氧气存在。

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