G5149
Gly-Gln monohydrate
≥97% (HPLC), powder
Synonym(s):
Glycyl-L-glutamine
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About This Item
Empirical Formula (Hill Notation):
C7H13N3O4 · H2O
CAS Number:
Molecular Weight:
221.21
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Assay:
≥97% (HPLC)
Product Name
Gly-Gln monohydrate, ≥97% (HPLC)
Quality Segment
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
O.NCC(=O)N[C@@H](CCC(N)=O)C(O)=O
InChI
1S/C7H13N3O4.H2O/c8-3-6(12)10-4(7(13)14)1-2-5(9)11;/h4H,1-3,8H2,(H2,9,11)(H,10,12)(H,13,14);1H2/t4-;/m0./s1
InChI key
KLFWVRQACSYLOH-WCCKRBBISA-N
General description
Glycyl-glutamine is a dipeptide form of L-glutamine. Gly-Gln dipeptide exhibits enhanced solubility and thermostability. Moreover, this compound rapidly hydrolyzes into glutamine and glycine following intravenous infusion. Glycine can protect myocardial cells from ischemic injury by preventing cellular membrane permeability. Furthermore, the supplementation of glycyl-glutamine dipeptide proves advantageous for myocardial preservation in rats, as it enhances cardiocyte energy metabolism and augments ATP and glutathione synthesis.
Glycyl-glutamine (gly-gln) is a dipeptide that is used as a substitute for glutamine in cell culture. Higher cell yields are obtained when this dipeptide is used instead of glutamine, where gly-gln affects substrate utilization and metabolism. Cell growth is higher as the concentrations of this dipeptide remain high, due to lower peptidase affinity.
Application
Gly-Gln monohydrate has been used:
- as a supplement in Dulbecco′s modified Eagle medium (DMEM) to culture equine embryos
- as a supplement in DMEM/F-12 to culture cleaved horse embryos
- in the human tubal fluid (HTF) medium to study ammonium accumulation in commercially available embryo culture media during incubation and storage
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Articles
Importance and uses of glutamine in hybridoma and mammalian cell culture
L-谷氨酰胺在杂交瘤细胞和哺乳动物细胞培养中的重要性和应用
Global Trade Item Number
| SKU | GTIN |
|---|---|
| G5149-5G | 04061833633236 |
| G5149-1G | 04061826152768 |