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G5419

Anti-GAD67 Antibody

clone K-87, purified antibody

Synonym(s):

Anti-GAD 67

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About This Item

MDL number:
MFCD06202147
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
K-87, monoclonal
Application:
IHC (p), WB
Citations:
27
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Product Name

Monoclonal Anti-Glutamic Acid Decarboxylase 67 (GAD67) antibody produced in mouse, clone K-87, purified antibody

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

K-87, monoclonal

mol wt

antigen 67 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500-1:20,000 (with antigen-retrieval step), western blot: 1:500-1:20,000 using mouse brain extract

isotype

IgG1κ

UniProt accession no.

Q99259

shipped in

dry ice

storage temp.

−70°C

target post-translational modification

unmodified

Gene Information

human ... GAD1(2571)
mouse ... Gad1(14415)
rat ... Gad1(24379)

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General description

Glutamic Acid Decarboxylase 67 (GAD67) is encoded by the gene glutamic acid decarboxylase 1 (GAD1). GAD1 gene is located on the human chromosome at 2q31.1. GAD67 is localized in the dendrites and cell bodies.

Immunogen

This peptide does not share homology with GAD65.
synthetic peptide from mouse GAD67 (amino acids 87-106).

Application

Monoclonal Anti-Glutamic Acid Decarboxylase 67 (GAD67) antibody is suitable for use in immunoblot, western blot (at 1:500-1:20,000 dilutions using mouse brain extract) and immunohistochemistry (at 1:500-1:20,000 dilutions in mouse brain sections).
Monoclonal anti-glutamic acid decarboxylase 67 (GAD67) antibody produced in mouse has been used in:
  • immunohistofluorescence
  • western blotting
  • immunohistochemistry.

Biochem/physiol Actions

Glutamic Acid Decarboxylase 67 (GAD67) is involved in the production of γ-amino butyric acid (GABA), a inhibitory neurotransmitter in the central nervous system (CNS). Deficiency of GAD67 leads to psychosis, schizophrenia and bipolar diseases.
Reacts specifically with GAD67. Does not crossreact with GAD65.

Physical form

Solution in phosphate buffered saline containing 0.01% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

常规特殊物品
低风险生物材料

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Certificates of Analysis (COA)

Lot/Batch Number
0000474794
0000474794
0000368650
0000352316
0000301788

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Minjung Kim et al.
PloS one, 7(2), e32043-e32043 (2012-03-01)
The analysis of co-localized protein expression in a tissue section is often conducted with immunofluorescence histochemical staining which is typically visualized in localized regions. On the other hand, chromogenic immunohistochemical staining, in general, is not suitable for the detection of
Mitsuhiro Tsuboi et al.
Cancer medicine, 8(9), 4189-4199 (2019-06-18)
In a previous genome-wide screening, we identified hypermethylated CpG islands around glutamate decarboxylase 1 (GAD1) in lung adenocarcinoma (LADC). In this study, we aimed to investigate the methylation and expression status of GAD1 and its prognostic value in patients with
Baohu Ji et al.
PloS one, 8(6), e66327-e66327 (2013-07-05)
It has been well established that schizophrenia patients display impaired NMDA receptor (NMDAR) functions as well as exacerbation of symptoms in response to NMDAR antagonists. Abnormal NMDAR signaling presumably contributes to cognitive deficits which substantially contribute to functional disability in
Silvia Rossi et al.
Brain, behavior, and immunity, 25(5), 947-956 (2010-10-14)
Synaptic dysfunction triggers neuronal damage in experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS). While excessive glutamate signaling has been reported in the striatum of EAE, it is still uncertain whether GABA synapses are altered. Electrophysiological recordings showed
Ying Chen et al.
Neuropharmacology, 60(7-8), 1075-1087 (2010-09-28)
GAD67 corresponds to one of two enzymes that decarboxylates glutamate to produce γ-aminobutyric acid, the main inhibitory neurotransmitter in the mammalian central nervous system, hence defining the cellular phenotype of a diverse set of inhibitory interneurons of the brain. Reduced
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Related Content

Data Sheet - G5419

Instructions

Global Trade Item Number

SKUGTIN
G5419-100UG04061833634691

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