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G5779

Gly-Pro-Arg-Pro amide

Name: Gly-Pro-Arg-Pro amide
Brand: SIGMA

≥97% (HPLC), Fibrin polymerization inhibitor

Synonym(s):

GPRP amide, Glycine-Proline-Arginine-Proline amide, Glycyl-L-prolyl-L-arginyl-L-prolinamide

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₃₂N₈O₄

CAS Number:

126047-75-4

Molecular Weight:

424.50

UNSPSC Code:

12352209

PubChem Substance ID:

24895231

NACRES:

NA.32

MDL number:

MFCD00237962

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Properties

Product Name

Gly-Pro-Arg-Pro amide, ≥97% (HPLC)

Quality Segment

200

assay

≥97% (HPLC)

UniProt accession no.

P02751, P04937, P11276

storage temp.

−20°C

SMILES string

NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(N)=O

InChI

1S/C18H32N8O4/c19-10-14(27)25-8-3-6-13(25)16(29)24-11(4-1-7-23-18(21)22)17(30)26-9-2-5-12(26)15(20)28/h11-13H,1-10,19H2,(H2,20,28)(H,24,29)(H4,21,22,23)/t11-,12-,13-/m0/s1

InChI key

SCCTZYGEMPQRCV-AVGNSLFASA-N

Gene Information

human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)

Description

General description

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein.

Application

Gly-Pro-Arg-Pro amide has been used-

as a constituent of buffer during fluid-phase and bound thrombin inhibition assays, to determine the activity of thrombin
for blocking fibrin polymerization and preventing fibrin clot formation in presence of α-thrombin, in blood obtained from mice
during preparation of human soluble fibrin, to block the polymerization of soluble fibrin

Biochem/physiol Actions

Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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