G5894
Glutaminase from Escherichia coli
Grade VII, lyophilized powder, 500-1,500 units/mg protein
Synonym(s):
L-Glutamine amidohydrolase
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About This Item
CAS Number:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Product Name
Glutaminase from Escherichia coli, Grade VII, lyophilized powder, 500-1,500 units/mg protein
type
Grade VII
form
lyophilized powder
specific activity
500-1,500 units/mg protein
composition
Protein, ~10% Lowry
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
Glutaminase catalyzes the conversion of glutamine to glutamate.
Other Notes
Chromatographically purified from Grade V
One unit will deaminate 1.0 μmole of L-glutamine per min at pH 4.9 at 37 °C.
Physical form
Lyophilized powder containing stabilizer and potassium succinate
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Javier Ampuero et al.
PloS one, 7(11), e49279-e49279 (2012-11-21)
To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients. To analyze the impact of metformin on glutaminase activity and ammonia production in vitro. Eighty-two cirrhotic patients with type
Natalie E Simpson et al.
Epigenetics, 7(12), 1413-1420 (2012-11-03)
The interplay of metabolism and epigenetic regulatory mechanisms has become a focal point for a better understanding of cancer development and progression. In this study, we have acquired data supporting previous observations that demonstrate glutamine metabolism affects histone modifications in
Krupa Shukla et al.
Journal of medicinal chemistry, 55(23), 10551-10563 (2012-11-16)
Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) is a potent and selective allosteric inhibitor of kidney-type glutaminase (GLS) that has served as a molecular probe to determine the therapeutic potential of GLS inhibition. In an attempt to identify more potent GLS inhibitors with improved
Eva M J Peters et al.
The Journal of investigative dermatology, 133(5), 1150-1160 (2012-12-14)
Determining hitherto uninvestigated and safe targets to halt the aging process is important in our aging society. Graying is a hallmark of the aging process and may be used to identify aging tissue for comparative analysis. Here we analyzed differential
L N Ramya et al.
Applied biochemistry and biotechnology, 167(8), 2144-2159 (2012-06-12)
Acute lymphoblastic leukaemia (ALL) is one of the leading types of malignant disorder seen in children. Viral infections, genetic factors and exposure to chemical carcinogens are some of the factors responsible for causing ALL. Treatment strategies followed for curing ALL
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