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Merck
CN

G6376

β-Glycerophosphate disodium salt hydrate

≤2.4 mol % α-isomer(based on C3H7O6PNa2 With x H2O)

Synonym(s):

BGP, Glycerol 2-phosphate disodium salt hydrate

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About This Item

Linear Formula:
(HOCH2)2CHOP(O)(ONa)2 · xH2O
CAS Number:
154804-51-0
Molecular Weight:
216.04 (anhydrous basis)
EC Number:
212-464-3
MDL number:
MFCD00149082
UNSPSC Code:
12352201
PubChem Substance ID:
57654215

Key Documents

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biological source

synthetic

form

powder

impurities

≤2.4 mol % α-isomer (based on C3H7O6PNa2 With x H2O)

mp

102-104 °C (lit.)

solubility

water: 100 mg/mL, clear, colorless to very faintly yellow

SMILES string

O.[Na+].[Na+].OCC(CO)OP([O-])([O-])=O

InChI

1S/C3H9O6P.2Na.H2O/c4-1-3(2-5)9-10(6,7)8;;;/h3-5H,1-2H2,(H2,6,7,8);;;1H2/q;2*+1;/p-2

InChI key

ROPZSVKNEIIIDE-UHFFFAOYSA-L

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Application

β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression.
Initiates differentiation of bone-marrow-derived stem cells embedded in a natural collagen/chitosan gel designed for tissue engineering.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
039K0041V
039K0041
059K0002
089K0124
059K0001

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Anthea Di Rita et al.
International journal of molecular sciences, 21(1) (2020-01-18)
The selective elimination of dysfunctional mitochondria through mitophagy is crucial for preserving mitochondrial quality and cellular homeostasis. The most described mitophagy pathway is regulated by a positive ubiquitylation feedback loop in which the PINK1 (PTEN induced kinase 1) kinase phosphorylates
Lucas R Brun et al.
SpringerPlus, 3, 676-676 (2014-12-19)
The aim of this study was to evaluate the effect of strontium ranelate (SrR) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of SrR in bisphosphonate-naïve patients (BP-naïve) compared to patients previously
Ya-Ting Deng et al.
PloS one, 10(8), e0136572-e0136572 (2015-09-01)
Echinocystic acid (EA) is a natural triterpone enriched in various herbs and has been used for medicinal purposes in China. In the present study, we systematically examined the effects of EA on ovariectomy-induced osteoporosis in rats for the first time.
Peng Sun et al.
Science advances, 6(12), eaaz0368-eaaz0368 (2020-03-29)
Adhesion G protein-coupled receptor G6 (Adgrg6; also named GPR126) single-nucleotide polymorphisms are associated with human height in multiple populations. However, whether and how GPR126 regulates body height is unknown. In this study, we found that mouse body length was specifically
Amit Alexander et al.
The Journal of pharmacy and pharmacology, 66(9), 1240-1250 (2014-05-16)
In this study, we have used melphalan (ML) as a model drug, used extensively for the treatment of breast cancer. Due to its remarkable haemolytic activity, clinical application of this drug is limited. We incorporated the two synthesized PEGylated melphalan
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