Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
UNSPSC Code:
12352204
biological source
human
Quality Segment
form
liquid
specific activity
≥14 U/mg Protein
mol wt
~60 kDa
suitability
suitable for molecular biology
UniProt accession no.
shipped in
wet ice
storage temp.
-10 to -25°C
Gene Information
human ... G6PD(2539)
General description
G6PD is a cytosolic oxidoreductase that catalyzes the first and rate-limiting step of the pentose phosphate pathway. The enzyme utilizes NADP⁺ as a cofactor to oxidize glucose-6-phosphate, generating NADPH and 6-phosphogluconolactone. G6PD is widely expressed in mammalian tissues and plays a critical role in maintaining cellular redox homeostasis. Structurally, it functions as a dimer or tetramer, and its activity is essential for protecting cells from oxidative damage.
Application
Glucose-6-phosphate dehydrogenase has been used in:
- Enzyme activity and NADPH generation assays
- Oxidative stress and redox biology studies
- Metabolic pathway analysis
- Studies of G6PD deficiency
Biochem/physiol Actions
G6PD catalyzes the oxidation of glucose-6-phosphate, generating NADPH and ribose-5-phosphate. NADPH is critical for maintaining cellular antioxidant systems and biosynthetic reactions. Dysfunction of G6PD affects redox homeostasis and is associated with hemolytic disorders.
Physical form
10mM KPB (pH 8.0), 0.150M NaCl, 10% glycerol
Preparation Note
Unit Definition: One unit oxidizes 1.0 umole D-glucose-6-phosphate to 6-phospho-D-gluconate per min in the presence of beta-NADP at pH 7.4 at 25°C
Storage Class
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.