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G7127

Guanosine 5′-diphosphate sodium salt

Name: Guanosine 5&#8242;-diphosphate sodium salt
Brand: SIGMA

≥96% (HPLC), synthetic (organic), powder

Synonym(s):

GDP

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₅N₅O₁₁P₂

CAS Number:

43139-22-6

Molecular Weight:

443.20

UNSPSC Code:

41106305

PubChem Substance ID:

24895291

NACRES:

NA.51

MDL number:

MFCD00070121

Assay:

≥96% (HPLC)

Biological source:

synthetic (organic)

Form:

powder

Solubility:

water: 50 mg/mL, clear, colorless

Storage temp.:

−20°C

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Product Name

Guanosine 5′-diphosphate sodium salt, Type I, ≥96% (HPLC)

biological source

synthetic (organic)

Quality Level

300

type

Type I

assay

≥96% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)c2ncn(C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O)c2N1

InChI

1S/C10H15N5O11P2.Na.H/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;

InChI key

PVMPTWQLNDHIEV-UHFFFAOYSA-N

Related Categories

Biochemicals

Nucleosides and Nucleotides

Phosphates

Application

Guanosine 5′-diphosphate sodium salt has been used:

in GTP-γ-35S functional assays
in Y1 agonist-stimulated [35S]- guanosine-5′-O-(3-thio)triphosphate (GTPγS) functional binding
in the expression and purification of recombinant proteins

Biochem/physiol Actions

Guanosine 5′-diphosphate (GDP) is the diphosphate nucleoside of the purine guanine. GDP and GTP are involved in and may be used to study cell signaling via G-coupled protein receptors (GCPR) and guanine nucleotide exchange factors (GEF) and a variety of GTPases.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT 1A agonist, as a putative mediator of quetiapine's antidepressant activity

Jensen N H, et al.

Neuropsychopharmacology, 33(10), 2303-2303 (2008)

Effect of in vivo exposure to ambient fine particles (PM2.5) on the density of dopamine D2-like receptors and dopamine-induced [35S]-GTPγS binding in rat prefrontal cortex and striatum membranes.

María-de-Los-Angeles Andrade-Oliva et al.

Environmental toxicology and pharmacology, 60, 58-65 (2018-04-17)

Male Sprague-Dawley rats (8-9 weeks-old) were exposed for three days (acute exposure) or eight weeks (subchronic exposure) to purified air or concentrated ambient fine particles, PM2.5 (≤2.5 μm; 15 to 18-fold of ambient air; 370-445 μg/m3). In membranes from rat prefrontal cortex

The eubacterial protein synthesis inhibitor pulvomycin interacts with archaeal elongation factor 1α from Sulfolobus solfataricus.

Nicola M Martucci et al.

Biochimie, 94(2), 503-509 (2011-09-20)

The effect of pulvomycin on the biochemical and fluorescence spectroscopic properties of the archaeal elongation factor 1α from Sulfolobus solfataricus (SsEF-1α), the functional analog of eubacterial EF-Tu, was investigated. The antibiotic was able to reduce in vitro the rate of protein

Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells.

Nami Kim et al.

Scientific reports, 7, 41066-41066 (2017-01-25)

This study characterizes the human metabolic response to piperine, a curcumin extract, and the details of its underlying molecular mechanism. Using

A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease

Yanagisawa M, et al.

The Journal of Biological Chemistry, 283(26), 18344-18354 (2008)

View All Related Papers

Protocols

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

LC/MS Analysis of Nucleotides SeQuant^® ZIC^®-cHILIC – Effect of pH

ZIC^®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

Global Trade Item Number

SKU	GTIN
G7127-10MG	04061833642382
G7127-100MG	04061833642375
G7127-25MG	04061833642405
G7127-500MG	04061833642412
G7127-1G	04061833642399

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