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G7252

Guanosine 5′-diphosphate tris salt from Saccharomyces cerevisiae

Name: Guanosine 5′-diphosphate tris salt from <I>Saccharomyces cerevisiae</I>
Brand: SIGMA

Type VI, ≥92.5%

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Synonym(s):

GDP

Empirical Formula (Hill Notation):

C₁₀H₁₅N₅O₁₁P₂

CAS Number:

103192-39-8

Molecular Weight:

443.20

MDL number:

MFCD00058344

PubChem Substance ID:

329799961

NACRES:

NA.51

type

Type VI

Quality Level

200

Assay

≥92.5%

shipped in

dry ice

storage temp.

−20°C

SMILES string

NC(CO)(CO)CO.NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H15N5O11P2.C4H11NO3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;5-4(1-6,2-7)3-8/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);6-8H,1-3,5H2/t3-,5-,6-,9-;/m1./s1

InChI key

YWMHXINREUQYRO-GWTDSMLYSA-N

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Biochem/physiol Actions

Guanosine 5′-diphosphate (GDP) is the diphosphate nucleoside of the purine guanine. GDP and GTP are involved in and may be used to study cell signaling via G-coupled protein receptors (GCPR) and guanine nucleotide exchange factors (GEF) and a variety of GTPases.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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The eubacterial protein synthesis inhibitor pulvomycin interacts with archaeal elongation factor 1α from Sulfolobus solfataricus.

Nicola M Martucci et al.

Biochimie, 94(2), 503-509 (2011-09-20)

The effect of pulvomycin on the biochemical and fluorescence spectroscopic properties of the archaeal elongation factor 1α from Sulfolobus solfataricus (SsEF-1α), the functional analog of eubacterial EF-Tu, was investigated. The antibiotic was able to reduce in vitro the rate of protein

Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.

Antonio Castro-Castro et al.

The EMBO journal, 30(19), 3913-3927 (2011-08-30)

The activation of the Rac1 GTPase during cell signalling entails its translocation from the cytosol to membranes, release from sequestering Rho GDP dissociation inhibitors (RhoGDI), and GDP/GTP exchange. In addition to those steps, we show here that optimal Rac1 activation

Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF.

Jakub A Bielnicki et al.

The Journal of biological chemistry, 286(40), 35163-35175 (2011-08-06)

PDZRhoGEF (PRG) belongs to a small family of RhoA-specific nucleotide exchange factors that mediates signaling through select G-protein-coupled receptors via Gα(12/13) and activates RhoA by catalyzing the exchange of GDP to GTP. PRG is a multidomain protein composed of PDZ

Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation.

Jason Lowery et al.

The Journal of biological chemistry, 286(42), 36898-36906 (2011-08-11)

ADP-ribosylation factors (ARFs) and their activating guanine nucleotide exchange factors (GEFs) play key roles in membrane traffic and signaling. All ARF GEFs share a ∼200-residue Sec7 domain (Sec7d) that alone catalyzes the GDP to GTP exchange that activates ARF. We

RIC8 is a guanine-nucleotide exchange factor for Galpha subunits that regulates growth and development in Neurospora crassa.

Sara J Wright et al.

Genetics, 189(1), 165-176 (2011-07-14)

Heterotrimeric (αβγ) G proteins are crucial components of eukaryotic signal transduction pathways. G-protein-coupled receptors (GPCRs) act as guanine nucleotide exchange factors (GEFs) for Gα subunits. Recently, facilitated GDP/GTP exchange by non-GPCR GEFs, such as RIC8, has emerged as an important

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