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Merck
CN

G7294

Guanidine hydrochloride solution

8 M, pH 8.5, buffered aqueous solution

Synonym(s):

Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, GuHCl, Guanidine HCl, Guanidinium chloride, Guanidium chloride

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About This Item

NACRES:
NA.25
UNSPSC Code:
12352209

Key Documents

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Product Name

Guanidine hydrochloride solution, 8 M, pH 8.5, buffered aqueous solution

form

buffered aqueous solution

concentration

8 M

Quality Level

200

color

colorless

pH

8.5

application(s)

diagnostic assay manufacturing

Related Categories

Application

Guanidine hydrochloride solution has been used:
  • as a denaturing agent during the preparation of HEK293T cells and in the resuspension buffer to prevent protein aggregation during the homogenization process in mouse tissue preparation.
  • for the extraction of total RNA from plant samples.
  • for the digestion of plasma and HDL proteins.
  • for the denaturation of proteins during the conformational stability assay of misfolded prion proteins.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
0000497691
0000497691
0000467810
0000467810
0000468072

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Urea and guanidine hydrochloride denaturation of ribonuclease, lysozyme, alpha-chymotrypsin, and beta-lactoglobulin.
R F Greene et al.
The Journal of biological chemistry, 249(17), 5388-5393 (1974-09-10)
The preparation of guanidine hydrochloride.
Nozaki, Yasuhiko
Methods in Enzymology, 26, 43-50 (1972)
Extended conformations of polypeptides and proteins in urea and guanidine hydrochloride.
Tiffany, M. Lois, and Samuel Krimm
Biopolymers, 12, 575-587 (1973)
Donna Wesolowski et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(40), 16582-16587 (2011-09-29)
Basic peptides covalently linked to nucleic acids, or chemically modified nucleic acids, enable the insertion of such a conjugate into bacteria grown in liquid medium and mammalian cells in tissue culture. A unique peptide, derived from human T cells, has
Xin Fang et al.
Molecular medicine reports, 23(3) (2021-01-27)
In diabetic animal models, high plasma/tissue levels of methylglyoxal (MG) are implicated in atherosclerosis. N‑acetylcysteine (NAC) is a cysteine prodrug that replenishes intracellular glutathione (GSH) levels, which can increase the elimination of MG in diabetes mellitus (DM). The present study
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