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G7504

Guanosine 3′,5′-cyclic monophosphate

Name: Guanosine 3&#8242;,5&#8242;-cyclic monophosphate
Brand: SIGMA

≥98% (HPLC), powder, intracellular mediator

Synonym(s):

cGMP, cyclic GMP

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₂N₅O₇P

CAS Number:

7665-99-8

Molecular Weight:

345.21

NACRES:

NA.77

PubChem Substance ID:

24895309

UNSPSC Code:

41106305

EC Number:

231-641-6

MDL number:

MFCD00070129

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

Guanosine 3′,5′-cyclic monophosphate, ≥98% (HPLC), powder

Quality Segment

200

assay

≥98% (HPLC)

form

powder

color

white

solubility

0.2 M NaHCO₃: 50 mg/mL

storage temp.

−20°C

SMILES string

NC1=NC(=O)c2ncn(C3OC4COP(O)(=O)OC4C3O)c2N1

InChI

1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)

InChI key

ZOOGRGPOEVQQDX-UHFFFAOYSA-N

Description

Biochem/physiol Actions

A major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides.

An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).

Features and Benefits

This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox and Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.