G7791
GW8510
solid
Synonym(s):
4-{[(7-Oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}-N-(2-pyridyl)benzenesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C21H15N5O3S2
CAS Number:
Molecular Weight:
449.51
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
assay
~98% (HPLC)
Quality Level
form
solid
solubility
DMSO: soluble
storage temp.
room temp
SMILES string
O=C1Nc2ccc3ncsc3c2\C1=C\Nc4ccc(cc4)S(=O)(=O)Nc5ccccn5
InChI
1S/C21H15N5O3S2/c27-21-15(19-16(25-21)8-9-17-20(19)30-12-24-17)11-23-13-4-6-14(7-5-13)31(28,29)26-18-3-1-2-10-22-18/h1-12,23H,(H,22,26)(H,25,27)/b15-11-
InChI key
GCYXEGSPUDSZJY-PTNGSMBKSA-N
Gene Information
human ... CDC2(983), CDK2(1017)
Biochem/physiol Actions
Initially characterized as an inhibitor of cyclin-dependent kinase 2 (CDK2), subsequent research has shown GW8510 to be non-selective.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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