Anti-phospho-GATA4 (pSer¹⁰⁵) antibody produced in rabbit

Anti-phospho-GATA4 (pSer¹⁰⁵) antibody produced in rabbit is suitable for western blotting at working dilution 1:500.

synthetic phosphopeptide derived from the region of GATA-4 that contains serine 105.

GATA-4 has a molar mass of 46kDa and belongs to the GATA family of zinc finger-containing transcription factors. It is involved in the development of cardiac hypertrophy and remodeling. It plays a crucial role in regulating basal and agonist or stress-induced gene expression in cardiac and smooth muscle cell types. Upon agonist stimulation via MEK1-ERK1/2, and weakly via JNK or p38 MAPKs, Ser¹⁰⁵ of GATA-4 is phosphorylated. Phosphorylation of GATA-4 by hepatocyte growth factor facilitates cell survival in cardiac muscle cells via MEK/ERK-dependent signaling pathway.

Solution in Dulbecco′s PBS, pH 7.3 with 1 mg/mL BSA and 0.05% Sodium Azide.

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