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G8377

Guanosine 5′-monophosphate disodium salt hydrate

Name: Guanosine 5&#8242;-monophosphate disodium salt hydrate
Brand: SIGMA

≥99%,from yeast, powder

Synonym(s):

5′-GMP-Na₂, 5′-Guanylic acid disodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₂N₅Na₂O₈P · xH₂O

CAS Number:

5550-12-9

Molecular Weight:

407.18 (anhydrous basis)

NACRES:

NA.51

PubChem Substance ID:

24895338

UNSPSC Code:

41106305

EC Number:

226-914-1

MDL number:

MFCD00151238

Beilstein/REAXYS Number:

3586801

Assay:

≥99%

Biological source:

yeast

Form:

powder

Solubility:

H₂O: soluble 50 mg/mL, clear, colorless to faintly yellow

Storage temp.:

room temp

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Product Name

Guanosine 5′-monophosphate disodium salt hydrate, from yeast, ≥99%

biological source

yeast

Quality Level

200

assay

≥99%

form

powder

solubility

H₂O: soluble 50 mg/mL, clear, colorless to faintly yellow

storage temp.

room temp

SMILES string

O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H14N5O8P.2Na.H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18);;;1H2/q;2*+1;/p-2/t3-,5-,6-,9-;;;/m1.../s1

InChI key

MEKWJTZTMVQYSU-CYCLDIHTSA-L

Related Categories

Biochemicals

Nucleosides and Nucleotides

Phosphates

Application

Guanosine 5′-monophosphate is suitable for use in:

the measurement of density and viscosity of nucleotide and along with the furanose sugar from 0.0004 to 0.0014mol/kg solution at 288.15, 293.15 and 298.15K at atmospheric pressure
the detection and validation of a transcreener assay for detection of AMP- and GMP-producing enzymes
the preparation of nucleotide standard during the quantitative profiling of nucleotides using capillary IC-MS/MS

Biochem/physiol Actions

Guanosine 5′-monophosphate (GMP) is a ribonucleoside monophospate which upon phosphorylation to GTP becomes incorporated into ribonucleic acids (RNAs) by various RNA polymerase(s). Guanosine-5′-monophosphate (GMP) can be used to study modulation of glutamatergic neurotransmission.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Spectroscopic Studies on Photoinduced Reactions of the Anticancer Prodrug, trans,trans,trans-[Pt(N3 )2 (OH)2 (py)2 ].

Robbin R Vernooij et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 24(22), 5790-5803 (2018-01-10)

The photodecomposition mechanism of trans,trans,trans-[Pt(N3 )2 (OH)2 (py)2 ] (1, py=pyridine), an anticancer prodrug candidate, was probed using complementary Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR), transient electronic absorption, and UV/Vis spectroscopy. Data fitting using Principal Component Analysis (PCA) and

Effects of 3 weeks GMP oral administration on glutamatergic parameters in mice neocortex.

Marcelo Ganzella et al.

Purinergic signalling, 8(1), 49-58 (2011-09-02)

Overstimulation of the glutamatergic system (excitotoxicity) is involved in various acute and chronic brain diseases. Several studies support the hypothesis that guanosine-5'-monophosphate (GMP) can modulate glutamatergic neurotransmission. The aim of this study was to evaluate the effects of chronically administered

Systemic administration of GMP induces anxiolytic-like behavior in rats.

Roberto Farina Almeida et al.

Pharmacology, biochemistry, and behavior, 96(3), 306-311 (2010-06-23)

The glutamatergic system has received considerable attention over the last few years as potential target to develop anxiolytic drugs. Guanine based purines (GBPs) play an important neurmodulatory effect in the glutamatergic system. Several studies have shown the ability of the

GMP prevents excitotoxicity mediated by NMDA receptor activation but not by reversal activity of glutamate transporters in rat hippocampal slices.

Simone Molz et al.

Brain research, 1231, 113-120 (2008-07-29)

Glutamate is the main excitatory neurotransmitter in the mammalian nervous system and is essential for its normal functions. However, overstimulation of glutamatergic system due to hyperactivation of NMDA receptors and/or impairment of glutamate reuptake system has been implicated in many

Volumetric and Viscometric Studies of Nucleosides, Nucleotides and Furanose Sugar in Aqueous Medium from 288.15 to 298.15 K.

Singh, M et al.

Iranian Journal of Chemistry and Chemical Engineering, 25, 53-66 (2006)

View All Related Papers

Protocols

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

LC/MS Analysis of Nucleotides SeQuant^® ZIC^®-cHILIC – Effect of pH

ZIC^®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

Global Trade Item Number

SKU	GTIN
G8377-25MG	04061831168853
G8377-25G	04061833643907
G8377-100G	04061833630235
G8377-1G	04061835557073
G8377-5G	04061833643945
G8377-10MG	04061831168846
G8377-500MG	04061833643938

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