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G8541

Ala-Gln

Name: Ala-Gln
Brand: SIGMA

200 mM, solution, sterile-filtered, Biotechnology Performance Certified

Synonym(s):

Alanyl-glutamine, Glutamine-S

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₅N₃O₄

CAS Number:

39537-23-0

Molecular Weight:

217.22

MDL number:

MFCD00133046

UNSPSC Code:

12352209

PubChem Substance ID:

24895343

NACRES:

NA.75

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grade

Biotechnology Performance Certified

Quality Level

400

sterility

sterile-filtered

form

solution

concentration

200 mM

impurities

endotoxin, tested

storage temp.

2-8°C

SMILES string

NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O

InChI

1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1

InChI key

HJCMDXDYPOUFDY-WHFBIAKZSA-N

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Amino Acids – Building Blocks of Life Science

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General description

Ala-Gln supplement provides a stable form of L-glutamine while in solution.

Application

Ala-Gln has been used as a supplement in Dulbecco′s Modified Eagle Medium (DMEM) media-rich in glucose and pyruvate to culture luciferase-expressing MDA-MB-231-luc tumor cells to measure the bioluminescence signals of cells leaking during intra-bone marrow transplantation (IBMT) from dissected long bones. It has also been used as a DMEM - high glucose media to culture human cell lines.

Other Notes

Contains the dipeptide L-Alanyl-L-glutamine. 200 mM supplied in 0.85% NaCl.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Capacity of the medullary cavity of tibia and femur for intra-bone marrow transplantation in mice.

Dieter Fink et al.

PloS one, 14(11), e0224576-e0224576 (2019-11-08)

Intra-bone marrow transplantation (IBMT) has been adapted for mouse models to improve the seeding efficiency of transplanted hematopoietic stem and progenitor cells. Commonly used injection volumes for IBMT into the tibia differ between 10 and 40 μL even though considerable

Glutamine and antioxidants in the critically ill patient: a post hoc analysis of a large-scale randomized trial.

Daren K Heyland et al.

JPEN. Journal of parenteral and enteral nutrition, 39(4), 401-409 (2014-05-08)

The recent large randomized controlled trial of glutamine and antioxidant supplementation suggested that high-dose glutamine is associated with increased mortality in critically ill patients with multiorgan failure. The objectives of the present analyses were to reevaluate the effect of supplementation

Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues.

Marek Bartosovic et al.

Nature biotechnology, 39(7), 825-835 (2021-04-14)

In contrast to single-cell approaches for measuring gene expression and DNA accessibility, single-cell methods for analyzing histone modifications are limited by low sensitivity and throughput. Here, we combine the CUT&Tag technology, developed to measure bulk histone modifications, with droplet-based single-cell

Structure and Function of the Bacterial Protein Toxin Phenomycin.

Bente K Hansen et al.

Structure (London, England : 1993), 28(5), 528-539 (2020-03-30)

Phenomycin is a bacterial mini-protein of 89 amino acids discovered more than 50 years ago with toxicity in the nanomolar regime toward mammalian cells. The protein inhibits the function of the eukaryotic ribosome in cell-free systems and appears to target translation

Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer.

Hiroshi Ono et al.

Cancer medicine, 3(3), 632-642 (2014-03-05)

Small-cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. To identify accurate predictive biomarkers and effective therapeutic modalities, we focus on a long noncoding RNA, Hox transcript antisense intergenic RNA (HOTAIR), and investigated its expression, cellular

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Global Trade Item Number

SKU	GTIN
G8541-100ML	04061833644119
G8541-100MLSTAB	04065272820318
G8541-10L	04061837035265
G8541-20ML	04061833644140

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