G8923
GANT58
≥98% (HPLC)
Synonym(s):
2,3,4,5-Tetra(4-pyridyl)thiophene, 4,4′,4′′,4′′′-Thiene-2,3,4,5-tetrayltetrapyridine
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About This Item
Empirical Formula (Hill Notation):
C24H16N4S
CAS Number:
Molecular Weight:
392.48
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Quality level:
Quality Level
assay
≥98% (HPLC)
color
white to pale yellow
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
c1cc(ccn1)-c2sc(-c3ccncc3)c(-c4ccncc4)c2-c5ccncc5
InChI
1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H
InChI key
USWLOKMMUTWFMD-UHFFFAOYSA-N
Biochem/physiol Actions
GANT58 is a Hedgehog signaling pathway inhibitor.
GANT58 is a Hedgehog signaling pathway inhibitor. GANT58 inhibits the hedgehog signaling pathway downstream of Smo. GANT58 inhibits Gli transcriptional activity, and reduces cellular levels of the Hh pathway components Gli1, Shh, and patched.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Alessandra Ciucci et al.
PloS one, 8(3), e60145-e60145 (2013-04-05)
Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of several cancers including medulloblastoma, glioblastoma, melanoma as well as pancreas, colorectal, and prostate carcinomas. Here we investigated the role of the transcription factor Gli1 in ovarian cancer.
Ferdinando Maria Milazzo et al.
Frontiers in oncology, 9, 1534-1534 (2020-02-11)
Targeted therapy using monoclonal antibodies conjugated to toxins is gaining space in the treatment of cancer. Here, we report the anti-tumor effect of a new antibody drug conjugate (ADC) delivering a HDAC inhibitor to ErbB2+ solid tumors. Trastuzumab was partially
Helen O Oladapo et al.
Cancer letters, 411, 136-149 (2017-10-03)
Activation of the Hedgehog (Hh) pathway effector GLI1 is linked to tumorigenesis and invasiveness in a number of cancers, with targeting of GLI1 by small molecule antagonists shown to be effective. We profiled a collection of GLI antagonists possessing distinct
Anuka Sharma et al.
Journal of cellular physiology (2019-02-05)
Resistance to therapy and metastasis remains one of the leading causes of mortality due to cervical cancer despite advances in detection and treatment. The mechanism of epithelial to mesenchymal transition (EMT) provides conceptual explanation to the invasiveness and metastatic spread
Joseph Vanderburgh et al.
ACS nano, 14(1), 311-327 (2020-01-03)
Breast cancer patients are at high risk for bone metastasis. Metastatic bone disease is a major clinical problem that leads to a reduction in mobility, increased risk of pathologic fracture, severe bone pain, and other skeletal-related events. The transcription factor
Global Trade Item Number
| SKU | GTIN |
|---|---|
| G8923-5MG | 04061833218853 |
| G8923-25MG | 04061833218846 |
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