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G9137

Gly-Pro 4-methoxy-β-naphthylamide

Name: Gly-Pro 4-methoxy-β-naphthylamide
Brand: SIGMA

dipeptidylpeptidase IV substrate

Synonym(s):

H-Gly-Pro-4MbNA

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₁N₃O₃

CAS Number:

42761-76-2

Molecular Weight:

327.38

NACRES:

NA.32

PubChem Substance ID:

24895363

UNSPSC Code:

12352204

MDL number:

MFCD00037726

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Properties

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

COc1cc(NC(=O)C2CCCN2C(=O)CN)cc3ccccc13

InChI

1S/C18H21N3O3/c1-24-16-10-13(9-12-5-2-3-6-14(12)16)20-18(23)15-7-4-8-21(15)17(22)11-19/h2-3,5-6,9-10,15H,4,7-8,11,19H2,1H3,(H,20,23)

InChI key

LSZPYDQEJZWJIJ-UHFFFAOYSA-N

Description

General description

Substrate for Dipeptidyl Aminopeptidase IV

Application

Gly-Pro 4-methoxy-β-naphthylamide has been used as a substrate to evaluate the dipeptidyl peptidase-4 (DPP4) enzymatic activity.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Differences in kidney-specific DPP-4 inhibition by linagliptin and sitagliptin.

Gerd Luippold et al.

Diabetes research and clinical practice, 143, 199-203 (2018-07-22)

The two dipeptidyl peptidase (DPP)-4 inhibitors, linagliptin and sitagliptin, were shown to exert different binding kinetics in vitro. Twenty-four hours after oral dosing particularly in vivo inhibition of renal-specific DPP-4 activity was more sustained in Sprague Dawley rats after exposure

Elevated CD26 Expression by Skin Fibroblasts Distinguishes a Profibrotic Phenotype Involved in Scar Formation Compared to Gingival Fibroblasts.

Wesley Mah et al.

The American journal of pathology, 187(8), 1717-1735 (2017-06-24)

Compared to skin, wound healing in oral mucosa is faster and produces less scarring, but the mechanisms involved are incompletely understood. Studies in mice have linked high expression of CD26 to a profibrotic fibroblast phenotype, but this has not been