Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit

The metabotropic glutamate receptors consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors, involved in the fast excitatory synaptic transmission. Glutamate also regulates ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins, called metabotropic glutamate receptors.

synthetic peptide corresponding to the sequence of amino acids 1116-1130 of rat metabotropic glutamate receptor 1A (mGluR1a).

Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit is suitable for use as a primary antibody at a working dilution of 1:1500 using extracts from mouse brain It is suitable for immunohistochemistry at a working dilution of 1:500 and for immunoblotting at a working dilution of 1:1000.

Glutamate Receptor 1 is a G-protein coupled receptor for glutamate. The role of the metabotropic receptors in pain and pathology is being studied for therapeutic potential. Glutamate receptors are important mediators of excitatory amino acid neurotransmission. The α isomer of this receptor is a disulfide-linked homodimer and its activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Mutations in this gene causes autosomal-recessive congenital cerebellar ataxia.

This antibody does not react with other splice variants or mGluR5.

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol

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