GW20081F
Anti-Histone H1,1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
5
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
manufacturer/tradename
Genway 15-288-20081F
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HIST1H1A(3024)
Application
Anti-Histone H1,1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Histone H1.1 is a protein encoded by the HIST1H1A gene in humans and the gene is expressed in testis and thymus, but not in other human tissues. It is located on chromosome 6(6p21-p22) containing 55 histone genes. ist1 on mouse chromosome 13 contains 51 histone genes. There are 2 different human H1 histones coding genes that are differentiated mainly due to the N- and C-terminal H1 domains, whereas the central part of the protein is highly conserved. Histone H1 is a fundamental chromosomal protein and is associated with the maintenance of higher-ordered chromatin organization. It functions in the compaction of chromatin into higher order structures and its modulation is an important step in the potentiation/depotentiation of chromatin structure for transcription. H1 binds less tightly than other histones to DNA in chromatin and can readily exchange in living cells.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
低风险生物材料
常规特殊物品
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M A Lever et al.
Nature, 408(6814), 873-876 (2000-12-29)
The considerable length of DNA in eukaryotic genomes requires packaging into chromatin to fit inside the small dimensions of the cell nucleus. Histone H1 functions in the compaction of chromatin into higher order structures derived from the repeating 'beads on
S Eick et al.
European journal of cell biology, 49(1), 110-115 (1989-06-01)
The genes coding for two different human H1 histones were isolated, and the primary structures were deduced from the nucleotide sequences. The genes differ from each other and from any other vertebrate H1 structure described until now. The differences occur
William F Marzluff et al.
Genomics, 80(5), 487-498 (2002-11-01)
The multigene family encoding the five classes of replication-dependent histones has been identified from the human and mouse genome sequence. The large cluster of histone genes, HIST1, on human chromosome 6 (6p21-p22) contains 55 histone genes, and Hist1 on mouse
P Burfeind et al.
Human genetics, 94(6), 633-639 (1994-12-01)
The expression of a human histone H1 isoform (H1.1) was studied in several human tissues. Northern blot analysis has revealed that this gene is expressed in testis and thymus, but not in other human tissues. In this report, we demonstrate
Kohsuke Kato et al.
Journal of cell science, 124(Pt 19), 3254-3265 (2011-09-24)
Linker histone H1 is a fundamental chromosomal protein involved in the maintenance of higher-ordered chromatin organization. The exchange dynamics of histone H1 correlates well with chromatin plasticity. A variety of core histone chaperones involved in core histone dynamics has been
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