Histone H1.1 native protein.

Immunogen Sequence: GI # 121903, sequence 1-104

Anti-Histone H1,1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Histone H1.1 is a protein encoded by the HIST1H1A gene in humans and the gene is expressed in testis and thymus, but not in other human tissues. It is located on chromosome 6(6p21-p22) containing 55 histone genes. ist1 on mouse chromosome 13 contains 51 histone genes. There are 2 different human H1 histones coding genes that are differentiated mainly due to the N- and C-terminal H1 domains, whereas the central part of the protein is highly conserved. Histone H1 is a fundamental chromosomal protein and is associated with the maintenance of higher-ordered chromatin organization. It functions in the compaction of chromatin into higher order structures and its modulation is an important step in the potentiation/depotentiation of chromatin structure for transcription. H1 binds less tightly than other histones to DNA in chromatin and can readily exchange in living cells.

Solution in phosphate buffered saline containing 0.02% sodium azide.

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