GW21339
Anti-ITGA3 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-CD49c, Anti-Integrin α-3, Anti-VL3A
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
5
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat
manufacturer/tradename
Genway 15-288-21339
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ITGA3(3675)
Application
Anti-ITGA3 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Integrin α-3 is a protein encoded by the ITGA3 gene in humans and is a member of the integrin family of cell adhesion receptors. It is a transmembrane integrin receptor subunit for various laminin isoforms that mediates signals between the cells and their microenvironment. ITGA3 plays an important role in the maintenance of tissue integrity. It may function as a receptor for fibronectin, laminin, and collagen. ITGA3 plays a central role in the interplay of cells, morphogens and ECM and is required for proper nephrogenesis. It acts as a potential marker protein for cells undergoing enhanced Epithelial-mesenchymal transition (EMT) and for cancer cells with aggressive phenotypes.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Takuya Shirakihara et al.
Cancer science, 104(9), 1189-1197 (2013-06-22)
Epithelial-mesenchymal transition (EMT) is a crucial event in wound healing, tissue repair, and cancer progression in adult tissues. Transforming growth factor (TGF)-β induces EMT in mouse epithelial cells. During prolonged treatment, TGF-β successively induces myofibroblastic differentiation with increased expression of
Y Takada et al.
The Journal of cell biology, 115(1), 257-266 (1991-10-01)
alpha 3 beta 1 (VLA-3), a member of the integrin family of cell adhesion receptors, may function as a receptor for fibronectin, laminin, and collagen. A partial cDNA clone (2.4 kb) for the human alpha 3 subunit was selected from
S D Jones et al.
Biochemical and biophysical research communications, 248(3), 896-898 (1998-08-15)
The alpha 3 beta 1 integrin is a receptor for various laminin isoforms and plays an important role in the maintenance of tissue integrity. We have characterized the genomic structure of the complete gene for the human alpha 3 integrin
Cristina Has et al.
The New England journal of medicine, 366(16), 1508-1514 (2012-04-20)
Integrin α(3) is a transmembrane integrin receptor subunit that mediates signals between the cells and their microenvironment. We identified three patients with homozygous mutations in the integrin α(3) gene that were associated with disrupted basement-membrane structures and compromised barrier functions
Rachel Shukrun et al.
PloS one, 9(3), e90879-e90879 (2014-03-14)
The development of the mammalian kidney is a highly complex process dependent upon the interplay of various cell types, secreted morphogens, and the extra-cellular matrix (ECM). Although integrins are the most important receptors for ECM proteins and are ubiquitously expressed
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