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GW22779

Sigma-Aldrich

Anti-GSK3b antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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MDL number:
MFCD01633410
NACRES:
NA.41

biological source

chicken

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, rat

manufacturer/tradename

Genway 15-288-22779

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI accession no.

NP_002084.2

UniProt accession no.

P49841

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GSK3B(2932)

Immunogen

Immunogen Sequence: GI # 21361340, sequence 21-36
Synthetic peptide sequence of glycogen synthase kinase 3β.

Application

Anti-GSK3β antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Glycogen synthase kinase 3β is an enzyme encoded by the GSK3B gene in humans. It is closely related to protein-serine kinases and acts as an inhibitory component of Wnt signalling during embryonic development, and cell proliferation in adult tissues. GSK-3β helps in facilitating NF-κB function. It is a key endogenous factor for specifically regulating oligodendrogenesis. The genotypes may interact with major depressive disorder (MDD). GSK-3β is a proline-directed kinase that helps in forming part of the wingless signaling pathway.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Zhifen Liu et al.
Psychiatry research, 223(3), 210-217 (2014-07-06)
GSK3β genotypes may interact with major depressive disorder (MDD) and may have a role in determining regional gray matter volume differences from healthy comparison subjects. However, any associations of GSK3β genotypes with MDD related to abnormal functional brain activity have
Kasum Azim et al.
Glia, 62(5), 778-779 (2014-03-29)
Oligodendrocytes, the myelinating cells of the CNS, are derived postnatally from oligodendrocyte precursors (OPs) of the subventricular zone (SVZ). However, the mechanisms that regulate their generation from SVZ neural stem cells (NSC) are poorly understood. Here, we have examined the
K F Lau et al.
Genomics, 60(2), 121-128 (1999-09-16)
Glycogen synthase kinase 3beta (GSK-3beta) is a proline-directed kinase that forms part of the wingless signaling pathway. Recent studies have shown that GSK-3beta phosphorylates the microtubule-associated protein tau in vitro and in cell culture. Tau is the principal component of
K P Hoeflich et al.
Nature, 406(6791), 86-90 (2000-07-14)
Glycogen synthase kinase-3 (GSK-3)-alpha and -beta are closely related protein-serine kinases, which act as inhibitory components of Wnt signalling during embryonic development and cell proliferation in adult tissues. Insight into the physiological function of GSK-3 has emerged from genetic analysis

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