Merck
CN

GW22779

Sigma-Aldrich

Anti-GSK3b antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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MDL编号:
NACRES:
NA.41

生物来源

chicken

偶联物

unconjugated

抗体形式

affinity isolated antibody

antibody product type

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

species reactivity

mouse, human, rat

manufacturer/tradename

Genway 15-288-22779

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... GSK3B(2932)

免疫原

Immunogen Sequence: GI # 21361340, sequence 21-36
Synthetic peptide sequence of glycogen synthase kinase 3β.

应用

Anti-GSK3β antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

生化/生理作用

Glycogen synthase kinase 3β is an enzyme encoded by the GSK3B gene in humans. It is closely related to protein-serine kinases and acts as an inhibitory component of Wnt signalling during embryonic development, and cell proliferation in adult tissues. GSK-3β helps in facilitating NF-κB function. It is a key endogenous factor for specifically regulating oligodendrogenesis. The genotypes may interact with major depressive disorder (MDD). GSK-3β is a proline-directed kinase that helps in forming part of the wingless signaling pathway.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

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Zhifen Liu et al.
Psychiatry research, 223(3), 210-217 (2014-07-06)
GSK3β genotypes may interact with major depressive disorder (MDD) and may have a role in determining regional gray matter volume differences from healthy comparison subjects. However, any associations of GSK3β genotypes with MDD related to abnormal functional brain activity have
Kasum Azim et al.
Glia, 62(5), 778-779 (2014-03-29)
Oligodendrocytes, the myelinating cells of the CNS, are derived postnatally from oligodendrocyte precursors (OPs) of the subventricular zone (SVZ). However, the mechanisms that regulate their generation from SVZ neural stem cells (NSC) are poorly understood. Here, we have examined the
K F Lau et al.
Genomics, 60(2), 121-128 (1999-09-16)
Glycogen synthase kinase 3beta (GSK-3beta) is a proline-directed kinase that forms part of the wingless signaling pathway. Recent studies have shown that GSK-3beta phosphorylates the microtubule-associated protein tau in vitro and in cell culture. Tau is the principal component of
K P Hoeflich et al.
Nature, 406(6791), 86-90 (2000-07-14)
Glycogen synthase kinase-3 (GSK-3)-alpha and -beta are closely related protein-serine kinases, which act as inhibitory components of Wnt signalling during embryonic development and cell proliferation in adult tissues. Insight into the physiological function of GSK-3 has emerged from genetic analysis

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