GW22829
Anti-PSMC5 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat
manufacturer/tradename
Genway 15-288-22829
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PSMC5(5705)
General description
PSMC5 (proteasome 26S subunit, ATPase, 5) is a regulatory subunit of the 26S proteasome belonging to the family of putative ATPases. It has structural homology with yeast Sug1p gene.
Immunogen
Immunogen Sequence: GI # 24497435, sequence 2-160
Recombinant proteasome 26S ATPase subunit 5
Application
Anti-PSMC5 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
26S protease regulatory subunit 8 is an enzyme encoded by the PSMC5 gene in humans and is important for the transcription of MHC II molecules. It has a role in regulating transcription of class I MHC and the MHC II-like molecules, HLA-DM and HLA-DO. PSMC5 acts as a key regulator of collagen contraction in primary human lung fibroblasts (a functional characteristic of myofibroblasts) and is a critical step in the process of fibrosis.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Michael F Nyp et al.
Respiratory research, 15, 19-19 (2014-02-18)
Myofibroblasts are the critical effector cells in the pathogenesis of pulmonary fibrosis which carries a high degree of morbidity and mortality. We have previously identified Type II TGFβ receptor interacting protein 1 (TRIP-1), through proteomic analysis, as a key regulator
K Akiyama et al.
FEBS letters, 363(1-2), 151-156 (1995-04-17)
The nucleotide sequence of a cDNA that encodes a new regulatory subunit, named p45, of the 26S proteasome of human hepatoblastoma HepG2 cells has been determined. The polypeptide predicted from the open reading frame consists of 406 amino acid residues
Yaritza Inostroza-Nieves et al.
Immunology letters, 147(1-2), 67-74 (2012-07-10)
The 19S proteasome regulatory particle plays a critical role in cellular proteolysis. However, emerging evidence suggests roles for 19S proteasome subunits in regulating yeast and mammalian transcription. It has been previously shown that Sug1 is important for the transcription of
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