H0161
Hyaluronic Acid Binding Protein bovine
lyophilized powder
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About This Item
Form:
lyophilized powder
Biological source:
bovine
biological source
bovine
Quality Level
form
lyophilized powder
technique(s)
immunofluorescence: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... VCAN(282662)
General description
Hyaluronic acid (HA) is a linear polysaccharide consisting of a repeating disaccharide of N-acetyl D-glucosamine (GlcNAc) and D-glucuronic acid (GlcA) with 1→4 interglycosidic linkages and these disaccharide repeating units are in turn linked by β (1→3) linkages. The number of repeating disaccharides in a HA molecule ranges from 2,000 to 25,000, which relates to a molecular mass of 106-107. The unique biological roles of HA is mainly due to the specific binding and interaction with HA-binding proteins also known as hyaladherins. Most hyaladherins is composed of a specific binding domain, also called a link module, which is composed of two α-helices and two antiparallel β-sheets.
Karl Meyer and John Palmer first isolated hyaluronic acid (HA) from the vitreous of bovine eyes. They coined the name “hyaluronic acid” as a conjugation of two words, hyaloid (vitreous) and uronic acid. HA has an extended random coil structure in physiological solution. Due to its random-coil structure and high molecular weight (HMW), HA forms very viscose and elastic solution with a huge hydrodynamic volume.
Application
Hyaluronic Acid Binding Protein bovine may be used for incubation of specimens for immunofluorescence analysis of human megakaryocytes.
Biochem/physiol Actions
Hyaluronic Acid Binding Protein (HABP) levels increases during oocyte maturation and it promotes cumulus expansion during in vitro maturation.
In addition to being an important structural component of tissues in all vertebrates, HA is also associated with several biological functions including intracellular signaling.
May be useful in hyaluronic acid binding or detection.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
监管及禁止进口产品
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Articles
Explore the role of hyaluronan, hyaluronic acid structure, hyaluronan synthesis & degradation, and more. Find GAGs, hydrogels, and scaffold kits.
Hyaluronan based hydrogels provide an improved model to study megakaryocyte-matrix interactions
Currao M, et al.
Experimental Cell Research, 346(1), 1-8 (2016)
A G Haus
Radiologic clinics of North America, 25(5), 913-928 (1987-09-01)
Today there are many dedicated mammographic x-ray units available that are capable of providing high-quality screen-film mammograms. Likewise, screen-film combinations designed for mammography are capable of providing images with appropriate contrast, resolution, and noise levels. Proper film processing is most
Identification of hyaluronic acid-binding proteins and their expressions in porcine cumulus-oocyte complexes during in vitro maturation
Yokoo M, et al.
Biology of Reproduction, 67(4), 1165-1171 (2002)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H0161-.1MG | 04061833420829 |