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Merck
CN

H0292

HIV-1 Tat Peptide

≥97% (HPLC), lyophilized powder

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About This Item

Empirical Formula (Hill Notation):
C64H118N32O14
CAS Number:
191936-91-1
Molecular Weight:
1559.83
UNSPSC Code:
12352202
PubChem Substance ID:
329815111
NACRES:
NA.32
MDL number:
MFCD07366706

Key Documents

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Product Name

HIV-1 Tat Protein (47-57),

SMILES string

NCCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI key

RAVVEEJGALCVIN-AGVBWZICSA-N

InChI

1S/C64H118N32O14/c65-25-3-1-11-39(89-50(101)38(13-5-27-81-59(69)70)88-48(99)34-87-49(100)37(67)33-35-19-21-36(97)22-20-35)51(102)90-40(12-2-4-26-66)52(103)91-41(14-6-28-82-60(71)72)53(104)92-43(16-8-30-84-62(75)76)55(106)95-45(23-24-47(68)98)57(108)94-42(15-7-29-83-61(73)74)54(105)93-44(17-9-31-85-63(77)78)56(107)96-46(58(109)110)18-10-32-86-64(79)80/h19-22,37-46,97H,1-18,23-34,65-67H2,(H2,68,98)(H,87,100)(H,88,99)(H,89,101)(H,90,102)(H,91,103)(H,92,104)(H,93,105)(H,94,108)(H,95,106)(H,96,107)(H,109,110)(H4,69,70,81)(H4,71,72,82)(H4,73,74,83)(H4,75,76,84)(H4,77,78,85)(H4,79,80,86)/t37-,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1

biological source

synthetic

form

lyophilized powder

solubility

deionized water: soluble

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

General description

HIV-1 trans-activator of transcription (Tat) is an 11kDa protein, which regulates HIV-1 gene expression at the level of transcription and protein synthesis. It is located in the nucleus of infected cells. HIV-1 Tat functions as a transcriptional activator for the synthesis of full-length viral RNA. It induces RNA splicing. Tat is an RNA binding protein, which particularly recognizes trans activator response element (TAR) from the HIV-1 RNA molecule.

Biochem/physiol Actions

Synthetic peptide that includes the sequence responsible for the cellular uptake of the human immunodeficiency virus-1 Tat protein, consisting of the polycationic region 49–57. The peptide is part of the protein transduction domain (PTD) and was shown to enable the introduction of nucleic acids into cells.

Physical form

Lyophilized from 0.1% aqueous trifluoroacetate (TFA).

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000454805
0000454804
0000454805
0000454804
0000382264

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What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?
Campbell GR and Loret EP
Retrovirology, 6(1), 50-50 (2009)
The HIV-1 Tat protein enhances splicing at the major splice donor site
Mueller N, et al.
Journal of Virology, 92(14), e01855-e01817 (2018)
Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein
Charnay N, et al.
Retrovirology, 6(1), 74-74 (2009)
Roles and functions of HIV-1 Tat protein in the CNS: an overview
Bagashev A and Sawaya BE
Virology Journal, 10(1), 358-358 (2013)
Esteban Cruz et al.
Cancers, 11(6) (2019-06-27)
Nanoparticle carriers offer the possibility of enhanced delivery of therapeutic payloads in tumor tissues due to tumor-selective accumulation through the enhanced permeability and retention effect (EPR). Gold nanoparticles (AuNP), in particular, possess highly appealing features for development as nanomedicines, such

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