H0417
Heparin Cofactor II from human plasma
aqueous glycerol solution, ≥90% (SDS-PAGE)
Synonym(s):
HCF2, HCII, SERPIND1
Product Name
Heparin Cofactor II from human plasma, aqueous glycerol solution, ≥90% (SDS-PAGE)
biological source
human plasma
assay
≥90% (SDS-PAGE)
form
aqueous glycerol solution
mol wt
~66 kDa
~66 kDa
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... SERPIND1(3053)
Biochem/physiol Actions
Heparin cofactor II (HCII), a member of the serpin superfamily, is a serine protease inhibitor that rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. In addition to its role in coagulation regulation, HCII may also participate in inflammation, atherosclerosis, and wound repair. For example, leukocyte-mediated degradation of HCII releases peptides that are chemotactic for neutrophils and monocytes which may promote acute inflammation and wound repair. It has also been reported that HCII and dermatan sulfate levels are elevated in pregnancy, suggesting that HCII may be protective against thrombosis during pregnancy.
Serine protease that inhibits thrombin, α-chymotrypsin, neutrophil cathepsin G, and Streptomyces griseus protease B.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Other Notes
HCII is tested for activity using a Thrombin inhibition assay. One unit will inhibit one NIH unit of Thrombin.
Physical form
50% aqueous glycerol solution (vol/vol)
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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