H0786
Heregulin-β, EGF Domain human
≥80% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution
Synonym(s):
HRG-β
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About This Item
biological source
human
Quality Segment
recombinant
expressed in E. coli
assay
≥80% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
185 kDa
packaging
pkg of 100 μg
storage condition
avoid repeated freeze/thaw cycles
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... NRG1(3084)
General description
Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.
Biochem/physiol Actions
Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases.
Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.
Physical form
Solution in phosphate buffered saline containing 30% glycerol.
Analysis Note
Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.
The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Instructions
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H0786-100UG | 04061833663462 |