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H1635

N-Hippuryl-His-Leu hydrate

Name: N-Hippuryl-His-Leu hydrate
Brand: SIGMA

chromogenic, ≥98% (HPLC), powder

Synonym(s):

N-Benzoyl-Gly-His-Leu, N-Hippuryl-L-histidyl-L-leucine hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₇N₅O₅ · xH₂O

CAS Number:

207386-83-2

Molecular Weight:

429.47 (anhydrous basis)

NACRES:

NA.32

PubChem Substance ID:

24895469

UNSPSC Code:

12352204

EC Number:

250-597-9

MDL number:

MFCD00149318

Beilstein/REAXYS Number:

5664178

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Product Name

N-Hippuryl-His-Leu hydrate, powder, ≥98% (HPLC)

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

acetic acid: ~50 mg/mL

storage temp.

−20°C

SMILES string

O.CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)c2ccccc2)C(O)=O

InChI

1S/C21H27N5O5.H2O/c1-13(2)8-17(21(30)31)26-20(29)16(9-15-10-22-12-24-15)25-18(27)11-23-19(28)14-6-4-3-5-7-14;/h3-7,10,12-13,16-17H,8-9,11H2,1-2H3,(H,22,24)(H,23,28)(H,25,27)(H,26,29)(H,30,31);1H2/t16-,17-;/m0./s1

InChI key

NWOJMNXIJBZMPK-QJHJCNPRSA-N

Gene Information

human ... ACE(1636), ACE2(59272)
mouse ... ACE3(217246)
rat ... ACE(11421), ACE2(70008), ACE3(498012)

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General description

Substrate for angiotensin converting enzyme.

Application

N-Hippuryl-His-Leu hydrate has been used in the measurement of angiotensin-converting enzyme (ACE) inhibitory activity using oyster hydrolysates, semimembranosus muscle samples, and rabbit lung acetone powder.

Biochem/physiol Actions

N-Hippuryl-His-Leu hydrate (HHL) can be used as an artificial substrate for angiotensin-converting enzyme (ACE).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000506150

0000506157

0000506156

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Characterization and ACE-inhibitory activity of amaranth proteins.

A Tiengo et al.

Journal of food science, 74(5), H121-H126 (2009-08-04)

Amaranth seeds have been considered as an excellent alternative or complementary source of food protein due to their balanced amino acid composition. However, their potential as a source of bioactive peptides has not been explored. The present study is aimed

In Silico Elucidation of the Molecular Recognition of Phenol Derivative Compounds and Hippuryl-histidyl-leucine as an Artificial Substrate with the Experimental Target: Angiotensin-converting Enzyme

Vazquez-Valaldez VH, et al.

Letters in Drug Design & Discovery (2020)

Prolonged atrial natriuretic peptide exposure stimulates guanylyl cyclase-a degradation.

Darcy R Flora et al.

Endocrinology, 151(6), 2769-2776 (2010-04-13)

Natriuretic peptide receptor-A (NPR-A), also known as guanylyl cyclase-A, is a transmembrane receptor guanylyl cyclase that is activated by the cardiac hormones atrial natriuretic peptide and B-type natriuretic peptide. Although ligand-dependent NPR-A degradation (also known as down-regulation) is widely acknowledged

Proximate composition, antihypertensive and antioxidative properties of the semimembranosus muscle from pork and beef after cooking and in vitro digestion.

Ida-Johanne Jensen et al.

Meat science, 96(2 Pt A), 916-921 (2013-11-12)

The aims of this study were to evaluate and compare proximate composition, antihypertensive activity and antioxidative capacity of the semimembranosus muscle from pork and beef and to study how these characteristics were affected by household preparation and subsequent digestion. The

Angiotensin I-converting enzyme inhibitor activity on egg albumen fermentation.

N Nahariah et al.

Asian-Australasian journal of animal sciences, 28(6), 855-861 (2015-02-27)

Lactobacillus plantarum is used for fermentation of fish products, meat and milk. However, the utilization of these bacteria in egg processing has not been done. This study was designed to evaluate the potential of fermented egg albumen as a functional

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Global Trade Item Number

SKU	GTIN
H1635-100MG	04061835545438
H1635-500MG	04061835512607
H1635-25MG	04061835557080
H1635-1G	04061833672686

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