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H1753

Hydralazine hydrochloride

Name: Hydralazine hydrochloride
Brand: SIGMA

synthetic (organic), ≥99% (TLC), DNA methyltransferase inhibitor, powder

Synonym(s):

1-Hydrazinophthalazine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₈H₈N₄ · HCl

CAS Number:

304-20-1

Molecular Weight:

196.64

NACRES:

NA.77

PubChem Substance ID:

24278461

UNSPSC Code:

12352200

EC Number:

206-151-0

MDL number:

MFCD00135998

Assay:

≥99% (TLC)

Form:

powder

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Properties

Product Name

Hydralazine hydrochloride,

biological source

synthetic (organic)

Quality Segment

100

assay

≥99% (TLC)

form

powder

mp

273 °C

solubility

water: 50 mg/mL

SMILES string

Cl[H].N\N=C1/N=NC=C2C=CC=CC12

InChI

1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;

InChI key

SECXUXOCDLQOBI-MKFZHGHUSA-N

Gene Information

human ... MAOA(4128), MAOB(4129)

Description

Application

Hydralazine hydrochloride has been used:

as a vasodilator to study its effects on hypertension in T-cell frequencies in juvenile rats
as a semicarbazide-sensitive amine oxidase (SSAO) inhibitor to study its effects on myocardial ischemia-reperfusion (I/R) injury
as a vasodilator to study its effects on insulin secretion and glucose tolerance

Biochem/physiol Actions

Hydralazine hydrochloride has therapeutic effects against heart failure and high blood pressure.

Inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression. Non-selective MAO-A/B inhibitor; antihypertensive; semicarbazide-sensitive amine oxidase inhibitor.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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pictograms

GHS06

signalword

Danger

hcodes

H301,H315,H319,H335

pcodes

P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c