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H1753

Hydralazine hydrochloride

Name: Hydralazine hydrochloride
Brand: SIGMA

synthetic (organic), ≥99% (TLC), DNA methyltransferase inhibitor, powder

Synonym(s):

1-Hydrazinophthalazine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₈H₈N₄ · HCl

CAS Number:

304-20-1

Molecular Weight:

196.64

NACRES:

NA.77

PubChem Substance ID:

24278461

UNSPSC Code:

12352200

EC Number:

206-151-0

MDL number:

MFCD00135998

Assay:

≥99% (TLC)

Form:

powder

Quality level:

100

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Product Name

Hydralazine hydrochloride,

biological source

synthetic (organic)

Quality Level

100

assay

≥99% (TLC)

form

powder

mp

273 °C

solubility

water: 50 mg/mL

SMILES string

Cl[H].N\N=C1/N=NC=C2C=CC=CC12

InChI

1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;

InChI key

SECXUXOCDLQOBI-MKFZHGHUSA-N

Gene Information

human ... MAOA(4128), MAOB(4129)

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Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Application

Hydralazine hydrochloride has been used:

as a vasodilator to study its effects on hypertension in T-cell frequencies in juvenile rats
as a semicarbazide-sensitive amine oxidase (SSAO) inhibitor to study its effects on myocardial ischemia-reperfusion (I/R) injury
as a vasodilator to study its effects on insulin secretion and glucose tolerance

Biochem/physiol Actions

Hydralazine hydrochloride has therapeutic effects against heart failure and high blood pressure.

Inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression. Non-selective MAO-A/B inhibitor; antihypertensive; semicarbazide-sensitive amine oxidase inhibitor.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS06

signalword

Danger

hcodes

H301,H315,H319,H335

pcodes

P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Angiotensin II induces interleukin-1β-mediated islet inflammation and β-cell dysfunction independently of vasoconstrictive effects.

Nadine S Sauter et al.

Diabetes, 64(4), 1273-1283 (2014-10-30)

Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin

Time-restricted feeding ameliorates non-alcoholic fatty liver disease through modulating hepatic nicotinamide metabolism via gut microbiota remodeling.

Ruijia Feng et al.

Gut microbes, 16(1), 2390164-2390164 (2024-08-18)

Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health concern, lacking specific therapeutic strategies. Time-restricted feeding (TRF) regimen demonstrated beneficial effects in NAFLD; however, the underlying mechanisms remain unclear. In this study, we established a NAFLD mouse model

Waste tea residue as a low cost adsorbent for removal of hydralazine hydrochloride pharmaceutical pollutant from aqueous media: An environmental remediation

Patil C S, et al.

Journal of Cleaner Production, 206, 407-418 (2019)

Diesel exhaust induced pulmonary and cardiovascular impairment: the role of hypertension intervention.

Urmila P Kodavanti et al.

Toxicology and applied pharmacology, 268(2), 232-240 (2013-02-19)

Exposure to diesel exhaust (DE) and associated gases is linked to cardiovascular impairments; however, the susceptibility of hypertensive individuals is poorly understood. The objectives of this study were (1) to determine cardiopulmonary effects of gas-phase versus whole-DE and (2) to

Utilizing novel TBI-on-a-chip device to link physical impacts to neurodegeneration and decipher primary and secondary injury mechanisms.

Edmond A Rogers et al.

Scientific reports, 12(1), 11838-11838 (2022-07-14)

While clinical observations have confirmed a link between the development of neurodegenerative diseases and traumatic brain injuries (TBI), there are currently no treatments available and the underlying mechanisms remain elusive. In response, we have developed an in vitro pendulum trauma

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Global Trade Item Number

SKU	GTIN
H1753-50G	04061832947860
H1753-10G	04061833697719
H1753-5G	04061833697726

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