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H2042

Histone H2A human

Name: Histone H2A human
Brand: SIGMA

Synonym(s):

Histone, Human

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About This Item

CAS Number:

1523001-32-2

NACRES:

NA.25

UNSPSC Code:

12352202

Form:

liquid

Biological source:

human

Recombinant:

expressed in E. coli

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Properties

biological source

human

Quality Segment

200

recombinant

expressed in E. coli

form

liquid

concentration

1 mg/mL

UniProt accession no.

Q16777

application(s)

cell analysis

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... H2AC20(8338)

Description

General description

Histones are highly basic chromatin proteins. They tightly pack and organize eukaryotic DNA to form nucleosomes. A nucleosome comprises an octameric core histone made of a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B. The 147 DNA base pairs are wrapped around the histone complex. H2A consists of a C-terminal tail extending out of the nucleosome core particle.

Application

Histone H2A human has been used as a neutrophil extracellular trap (NET) to study its effects on the membrane integrity and viability of macrophages (MFS) and dendritic cells (DCS). It has also been used in far-western blot analysis for protein identification.

Biochem/physiol Actions

Histones modulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. N and C terminal tails undergo post-translational modifications (PTMs) altering DNA wrapping and chromatin regulation.

Physical form

Supplied in 20 mM Na₃PO₄, pH 7.0, 0.3 M NaCl and 1 mM EDTA

Pictograms

GHS08

Signal Word

Danger

Hazard Codes

H350

Precautionary Statements

P201 - P308 + P313

Hazard Classifications

Carc. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)