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H2504

His-Leu

Name: His-Leu
Brand: SIGMA

≥98% (TLC), suitable for ligand binding assays

Synonym(s):

histidylleucine

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₂₀N₄O₃

CAS Number:

7763-65-7

Molecular Weight:

268.31

UNSPSC Code:

12352209

PubChem Substance ID:

24895501

NACRES:

NA.26

MDL number:

MFCD00037860

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Properties

Product Name

His-Leu,

assay

≥98% (TLC)

Quality Level

200

form

solid

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(N)Cc1cnc[nH]1)C(O)=O

InChI

1S/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)

InChI key

MMFKFJORZBJVNF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Histidylleucine (His-Leu); histidylglycine (His-Gly) and histidylserine (His-Ser) are N-terminal imidazole containing dipeptides used to study binding of metals such as copper, nickel and zinc.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Angiotensin-converting enzyme in human skeletal muscle. A simple in vitro assay of activity in needle biopsy specimens.

R Reneland et al.

Scandinavian journal of clinical and laboratory investigation, 54(2), 105-111 (1994-04-01)

The importance of skeletal muscle for human haemodynamics and metabolism makes it a suitable sample tissue for the measurement of angiotensin converting enzyme (ACE; EC 3.4.15.1). A study of serum and muscle angiotensin-converting enzyme was performed in 50 essential-hypertensive subjects.

Identification of enzymatically produced peptide fragments by liquid chromatography and mass spectrometry.

R Baranowski et al.

Analytical biochemistry, 121(1), 97-102 (1982-03-15)

Distribution and coexistence of corticotropin-releasing factor-, neurotensin-, enkephalin-, cholecystokinin-, galanin- and vasoactive intestinal polypeptide/peptide histidine isoleucine-like peptides in the parvocellular part of the paraventricular nucleus.

S Ceccatelli et al.

Neuroendocrinology, 49(3), 309-323 (1989-03-01)

The distribution of several peptides, corticotropin-releasing factor (CRF), neurotensin (NT), enkephalin (ENK), vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), cholecystokinin (CCK), thyrotropin-releasing hormone (TRH) and galanin (GAL) was studied in detail with immunohistochemistry in the various subdivisions of the

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Global Trade Item Number

SKU	GTIN
H2504-250MG	04061832884851
H2504-1G	04061826683521