H2504
His-Leu
≥98% (TLC), suitable for ligand binding assays
Synonym(s):
histidylleucine
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About This Item
Empirical Formula (Hill Notation):
C12H20N4O3
CAS Number:
Molecular Weight:
268.31
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
Product Name
His-Leu,
SMILES string
CC(C)CC(NC(=O)C(N)Cc1cnc[nH]1)C(O)=O
InChI
1S/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)
InChI key
MMFKFJORZBJVNF-UHFFFAOYSA-N
assay
≥98% (TLC)
form
solid
technique(s)
ligand binding assay: suitable
color
white to off-white
storage temp.
−20°C
Quality Level
Related Categories
Biochem/physiol Actions
Histidylleucine (His-Leu); histidylglycine (His-Gly) and histidylserine (His-Ser) are N-terminal imidazole containing dipeptides used to study binding of metals such as copper, nickel and zinc.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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H Iwata et al.
Biotechnology progress, 7(5), 412-418 (1991-09-01)
An immobilized metal affinity (IMA) hollow-fiber membrane was prepared by radiation-induced graft polymerization of glycidyl methacrylate (GMA) onto a porous polyethylene hollow fiber, followed by chemical conversion of the produced epoxide group into an iminodiacetate (IDA) group and its chelation
K Iwatsuki et al.
Clinical and experimental pharmacology & physiology, 20(7-8), 501-507 (1993-07-01)
1. The effects of peptide histidine isoleucine (PHI) on pancreatic exocrine secretion were investigated in preparations of the isolated and blood-perfused dog pancreas as compared with those of vasoactive intestinal peptide (VIP), secretin and glucagon. 2. Each peptide tested was
R Reneland et al.
Scandinavian journal of clinical and laboratory investigation, 54(2), 105-111 (1994-04-01)
The importance of skeletal muscle for human haemodynamics and metabolism makes it a suitable sample tissue for the measurement of angiotensin converting enzyme (ACE; EC 3.4.15.1). A study of serum and muscle angiotensin-converting enzyme was performed in 50 essential-hypertensive subjects.
Identification of enzymatically produced peptide fragments by liquid chromatography and mass spectrometry.
R Baranowski et al.
Analytical biochemistry, 121(1), 97-102 (1982-03-15)
S Ceccatelli et al.
Neuroendocrinology, 49(3), 309-323 (1989-03-01)
The distribution of several peptides, corticotropin-releasing factor (CRF), neurotensin (NT), enkephalin (ENK), vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), cholecystokinin (CCK), thyrotropin-releasing hormone (TRH) and galanin (GAL) was studied in detail with immunohistochemistry in the various subdivisions of the
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