H2915
HCK (230-497), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
JTK9
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
156-212 nmol/min·mg
mol wt
~57 kDa
UniProt accession no.
relevant disease(s)
cancer (leukemia)
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... HCK(3055)
General description
HCK (hematopoietic cell kinase), a protein-tyrosine kinase belonging to the Src family, is expressed in certain hemopoietic cells. It is especially prominent in cells of myeloid lineage, particularly mature granulocytes and monocytes.
Biochem/physiol Actions
HCK (hematopoietic cell kinase) gene is mapped to human chromosome 20q11-q12. This region on the chromosome urdergoes interstitial deletions in some acute myeloid leukemias and myeloproliferative disorders, thereby suggesting HCK participation in the pathogenesis of these conditions.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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