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H3035

Hydrocortisone 21-acetate

Name: Hydrocortisone 21-acetate
Brand: SIGMA

meets USP testing specifications

Synonym(s):

11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-acetate, 17-α-Hydroxycorticosterone acetate, 17-Hydroxycorticosterone 21-acetate, 21-Acetoxy-4-pregnene-11β,17α-diol-3,20-dione, 4-Pregnene-11β,17α,21-triol-3,20-dione 21-acetate

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₃₂O₆

CAS Number:

50-03-3

Molecular Weight:

404.50

UNSPSC Code:

41116107

NACRES:

NA.21

PubChem Substance ID:

24895547

EC Number:

200-004-4

Beilstein/REAXYS Number:

2066841

MDL number:

MFCD00037714

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Quality Level

200

agency

USP/NF, meets USP testing specifications

mp

223 °C (dec.) (lit.)

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key

ALEXXDVDDISNDU-JZYPGELDSA-N

Gene Information

human ... NR3C1(2908), SERPINA6(866)

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Application

Hydrocortisone 21-acetate is used as a stabilized form of the glucocorticoid in studies on stress and homeostasis.

pictograms

GHS08

signalword

Danger

hcodes

H360Df,H373

pcodes

P202 - P260 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品

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UVB photolysis of hydrocortisone 21-acetate.

Sergio Caffieri et al.

Journal of pharmaceutical and biomedical analysis, 47(4-5), 771-777 (2008-04-22)

Hydrocortisone 21-acetate (HCA) in methanol solution undergoes photodegradation under UVB light, as monitored by HPLC. Five main photoproducts have been isolated and characterized by means of NMR and mass spectroscopy. One of them derives from a Norrish I photoreaction which

Papular colpitis: a distinct clinical entity? Symptoms, signs, histopathological diagnosis, and treatment in a series of patients seen at the Rotterdam vulvar clinic.

Willem I van der Meijden et al.

Journal of lower genital tract disease, 15(1), 60-65 (2010-12-31)

To study demographic, clinical, and histopathological data as well as treatment outcome in women with papular colpitis. Data of women (n = 18) visiting the Rotterdam vulvar clinic and meeting the diagnostic criteria for papular colpitis were retrospectively analyzed using

Effectiveness of budesonide-succinate-dextran conjugate as a novel prodrug of budesonide against acetic acid-induced colitis in rats.

Jaleh Varshosaz et al.

International journal of colorectal disease, 25(10), 1159-1165 (2010-07-30)

Anti-inflammatory drugs with high potency and low systemic adverse effects, such as budesonide, are drugs of choice for the treatment of ulcerative colitis (UC). Budesonide controlled-release formulations are now being used to induce and maintain clinical remission of Crohn's disease.

Response to lactation induction differs by season of year and breed of dairy ewes.

B Ramírez Andrade et al.

Journal of dairy science, 91(6), 2299-2306 (2008-05-20)

Lactation artificially induced (ART) by steroid hormones and natural lactation (NAT) after lambing were compared in 2 dairy sheep breeds (Manchega and Lacaune) in 2 experiments conducted during winter and spring. In experiment 1, ART ewes (14 Manchega and 9

Dual excitation wavelength epifluorescence imaging of transmural electrophysiological properties in intact hearts.

Richard D Walton et al.

Heart rhythm, 7(12), 1843-1849 (2010-09-08)

Epifluorescence imaging using voltage-sensitive dyes has provided unique insights into cardiac electrical activity and arrhythmias. However, conventional dyes use blue-green excitation light, which has limited depth penetration. The aim of this study was to demonstrate that combining a short and

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Global Trade Item Number

SKU	GTIN
H3035-5G	04061833620724

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