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Merck
CN

H3035

Hydrocortisone 21-acetate

meets USP testing specifications

Synonym(s):

11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-acetate, 17-α-Hydroxycorticosterone acetate, 17-Hydroxycorticosterone 21-acetate, 21-Acetoxy-4-pregnene-11β,17α-diol-3,20-dione, 4-Pregnene-11β,17α,21-triol-3,20-dione 21-acetate

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About This Item

Empirical Formula (Hill Notation):
C23H32O6
CAS Number:
50-03-3
Molecular Weight:
404.50
UNSPSC Code:
41116107
NACRES:
NA.21
PubChem Substance ID:
24895547
EC Number:
200-004-4
Beilstein/REAXYS Number:
2066841
MDL number:
MFCD00037714

Key Documents

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Product Name

Hydrocortisone 21-acetate, meets USP testing specifications

InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key

ALEXXDVDDISNDU-JZYPGELDSA-N

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

agency

USP/NF
meets USP testing specifications

mp

223 °C (dec.) (lit.)

Quality Level

200

Gene Information

human ... NR3C1(2908), SERPINA6(866)

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Application

Hydrocortisone 21-acetate is used as a stabilized form of the glucocorticoid in studies on stress and homeostasis.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Repr. 1B - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
SLCJ9335
SLCH0501
SLCG8478
SLCD2195
SLBX7231

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Sai H S Boddu et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 26(1), 37-48 (2010-02-13)
This article describes the development and characterization of PLGA nanoparticles of dexamethasone (DEX), hydrocortisone acetate (HA), and prednisolone acetate (PA) suspended in thermosensitive gels indicated for the treatment of macular edema (ME). Nanoparticles were prepared by oil-in-water (O/W) emulsion and
Johanna Mandelin et al.
Acta dermato-venereologica, 90(2), 170-174 (2010-02-20)
A one-year, randomized, double-blind study was conducted in 80 patients with atopic dermatitis treated with tacrolimus ointment or a corticosteroid regimen (hydrocortisone acetate 1% ointment for head and neck, hydrocortisone butyrate 0.1% ointment for trunk and limbs) to compare efficacy
Nunzia Falco et al.
International journal of pharmaceutics, 441(1-2), 589-597 (2012-11-06)
The objective of the present study was to develop an anti-inflammatory prolonged action formulation for local injection in prefilled syringes. Hydrocortisone acetate (HA) was selected as a model corticosteroid drug to be incorporated in poly(lactic-co-glycolic) (PLGA) microspheres. The formulation was
Otto Chan et al.
Disability and rehabilitation, 30(20-22), 1697-1708 (2008-07-09)
To determine the effectiveness of high volume image guided injections (HVIGI) for chronic Achilles tendinopathy. We included in the study 30 consecutive patients (mean age 37.2 years, range 24 - 58 years) with Achilles tendinopathy for a mean of 35.8
B Ramírez Andrade et al.
Journal of dairy science, 91(6), 2299-2306 (2008-05-20)
Lactation artificially induced (ART) by steroid hormones and natural lactation (NAT) after lambing were compared in 2 dairy sheep breeds (Manchega and Lacaune) in 2 experiments conducted during winter and spring. In experiment 1, ART ewes (14 Manchega and 9
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