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Merck
CN

H3035

Hydrocortisone 21-acetate

meets USP testing specifications

Synonym(s):

11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-acetate, 17-α-Hydroxycorticosterone acetate, 17-Hydroxycorticosterone 21-acetate, 21-Acetoxy-4-pregnene-11β,17α-diol-3,20-dione, 4-Pregnene-11β,17α,21-triol-3,20-dione 21-acetate

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About This Item

Empirical Formula (Hill Notation):
C23H32O6
CAS Number:
50-03-3
Molecular Weight:
404.50
UNSPSC Code:
41116107
NACRES:
NA.21
PubChem Substance ID:
24895547
EC Number:
200-004-4
Beilstein/REAXYS Number:
2066841
MDL number:
MFCD00037714

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InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key

ALEXXDVDDISNDU-JZYPGELDSA-N

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

agency

USP/NF, meets USP testing specifications

mp

223 °C (dec.) (lit.)

Quality Level

200

Gene Information

human ... NR3C1(2908), SERPINA6(866)

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Application

Hydrocortisone 21-acetate is used as a stabilized form of the glucocorticoid in studies on stress and homeostasis.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Repr. 1B - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000527922
0000527922
SLCJ9335
SLCH0501
SLCG8478

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Willem I van der Meijden et al.
Journal of lower genital tract disease, 15(1), 60-65 (2010-12-31)
To study demographic, clinical, and histopathological data as well as treatment outcome in women with papular colpitis. Data of women (n = 18) visiting the Rotterdam vulvar clinic and meeting the diagnostic criteria for papular colpitis were retrospectively analyzed using
Sergio Caffieri et al.
Journal of pharmaceutical and biomedical analysis, 47(4-5), 771-777 (2008-04-22)
Hydrocortisone 21-acetate (HCA) in methanol solution undergoes photodegradation under UVB light, as monitored by HPLC. Five main photoproducts have been isolated and characterized by means of NMR and mass spectroscopy. One of them derives from a Norrish I photoreaction which
Liliana Losada et al.
PLoS pathogens, 11(4), e1004834-e1004834 (2015-04-25)
Invasive aspergillosis (IA) due to Aspergillus fumigatus is a major cause of mortality in immunocompromised patients. The discovery of highly fertile strains of A. fumigatus opened the possibility to merge classical and contemporary genetics to address key questions about this
B Ramírez Andrade et al.
Journal of dairy science, 91(6), 2299-2306 (2008-05-20)
Lactation artificially induced (ART) by steroid hormones and natural lactation (NAT) after lambing were compared in 2 dairy sheep breeds (Manchega and Lacaune) in 2 experiments conducted during winter and spring. In experiment 1, ART ewes (14 Manchega and 9
Jaleh Varshosaz et al.
International journal of colorectal disease, 25(10), 1159-1165 (2010-07-30)
Anti-inflammatory drugs with high potency and low systemic adverse effects, such as budesonide, are drugs of choice for the treatment of ulcerative colitis (UC). Budesonide controlled-release formulations are now being used to induce and maintain clinical remission of Crohn's disease.
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