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H3128

Calconcarboxylic acid

suitable for use as an indicator for the titration of calcium

Synonym(s):

2-Hydroxy-1-(2-hydroxy-4-sulfo-1-naphthylazo)-3-naphthoic acid, 3-Hydroxy-4-(2-hydroxy-4-sulfo-1-naphthylazo)naphthalene-2-carboxylic acid, Patton and Reeder’s reagent

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About This Item

Empirical Formula (Hill Notation):
C21H14N2O7S
CAS Number:
3737-95-9
Molecular Weight:
438.41
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
24895550
EC Number:
223-117-0
Beilstein/REAXYS Number:
727492
MDL number:
MFCD00004078
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Quality Segment

100

form

powder

mp

300 °C

solubility

1 M NaOH: 10 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

OC(=O)c1cc2ccccc2c(N=Nc3c(O)cc(c4ccccc34)S(O)(=O)=O)c1O

InChI

1S/C21H14N2O7S/c24-16-10-17(31(28,29)30)13-7-3-4-8-14(13)18(16)22-23-19-12-6-2-1-5-11(12)9-15(20(19)25)21(26)27/h1-10,24-25H,(H,26,27)(H,28,29,30)/b23-22-

InChI key

MVQBFZXBLLMXGS-FCQUAONHSA-N

General description

Calconcarboxylic acid is a useful indicator for calcium titrations with EDTA in the presence of magnesium. It is also required for the staining of proteins in gels.
Calconcarboxylic acid is also known as Patton-Reeder indicator and is used in the determination of calcium at pH 12. Calconcarboxylic acid is a chelating agent and is used in the preparation of chelating sorbent along with chemically modified silica LiChroprep-NH2, for trace metal analysis. Calconcarboxylic acid coupled with 3-aminopropyltriethoxysilane (APS-CCA), a fluorescent probe, facilitates the medical detection of Ca2+ ions in the blood with minimal blood backgrounds using hydrophobic hexadecyltrimethoxysilane (HDS) as substrate in fluorimetric microarray method.

Application

Calconcarboxylic acid (CCA) has been used in the preparation of poly-CCA film for leukemia diagnosis by immobilization, hybridization of DNA and detection by methylene blue and differential pulse voltammetry.

Analysis Note

Contains an inert diluent.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000519544
0000519544
0000511208
SHBT1967
0000418083

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Separation Methods In Proteomics (2005)
An electrochemical biosensor for detection of PML/RARA fusion gene using capture probe covalently immobilized onto poly-calcon carboxylic acid modified glassy carbon electrode
Wei N, et al.
Talanta, 78(4-5), 1227-1234 (2009)
A high-throughput fluorimetric microarray with enhanced fluorescence and suppressed ?coffee-ring? effects for the detection of calcium ions in blood
Ding Y, et al.
Scientific Reports, 6, 38602-38602 (2016)
View All Related Papers

Global Trade Item Number

SKUGTIN
H3128-25G04061833792605
H3128-5G04061833792612
H3128-100G04061833792582