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H3541

HIPK3 (163-562), active, His tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

DYRK6, FIST3, PKY, YAK1

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About This Item

NACRES:
NA.32
UNSPSC Code:
12352200
Form:
buffered aqueous glycerol solution
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells
Mol wt:
~49 kDa

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Product Name

HIPK3 (163-562), active, His tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

41-56 nmol/min·mg

mol wt

~49 kDa

UniProt accession no.

Q9H422

shipped in

dry ice

storage temp.

−70°C

Quality Level

200

Gene Information

human ... HIPK3(10114)

Biochem/physiol Actions

HIPK3 (homeodomain-interacting protein kinase 3) is a nuclear serine/threonine protein kinase and mainly controls death receptor signaling. HIPK3 is involved in the transcriptional corepression, cell differentiation, growth suppression and apoptosis. It is up-regulated in prostate cancer cells, resulting in increased resistance to Fas receptor-mediated apoptosis by disturbing association between FADD (fas-associated death domain) and caspase 8.

General description

HIPK3 (homeodomain-interacting protein kinase 3) is strongly expressed in the heart and muscle tissues. It is up-regulated in multidrug-resistant cells.

Physical form

Supplied in 50 mM Sodium Phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLCJ0400
SLBR2716V

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Hsin-Chieh Lan et al.
Molecular and cellular biology, 27(6), 2027-2036 (2007-01-11)
Steroids are synthesized in adrenal glands and gonads under the control of pituitary peptides. These peptides bind to cell surface receptors to activate the cyclic AMP (cAMP) signaling pathway leading to an increase of steroidogenic gene expression. Exactly how cAMP
D A Begley et al.
Gene, 200(1-2), 35-43 (1997-12-31)
We have previously shown that several protein kinases are present in higher activity levels in multidrug resistant cell lines, such as KB-V1. We have now isolated a gene that codes for a putative protein kinase, PKY, of over 130 kDa
James F Curtin et al.
The Journal of biological chemistry, 279(17), 17090-17100 (2004-02-10)
Elevated endogenous JNK activity and resistance to Fas receptor-mediated apoptosis have recently been implicated in progression of prostate cancer and can promote resistance to apoptosis in response to chemotherapeutic drugs. In addition, JNK has been demonstrated to promote transformation of

Related Content

Data Sheet - H3541

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