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H3541

HIPK3 (163-562), active, His tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

DYRK6, FIST3, PKY, YAK1

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About This Item

NACRES:
NA.32
UNSPSC Code:
12352200
Form:
buffered aqueous glycerol solution
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells
Mol wt:
~49 kDa
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recombinant

expressed in baculovirus infected Sf9 cells

Quality Segment

200

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

41-56 nmol/min·mg

mol wt

~49 kDa

UniProt accession no.

Q9H422

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... HIPK3(10114)

General description

HIPK3 (homeodomain-interacting protein kinase 3) is strongly expressed in the heart and muscle tissues. It is up-regulated in multidrug-resistant cells.

Biochem/physiol Actions

HIPK3 (homeodomain-interacting protein kinase 3) is a nuclear serine/threonine protein kinase and mainly controls death receptor signaling. HIPK3 is involved in the transcriptional corepression, cell differentiation, growth suppression and apoptosis. It is up-regulated in prostate cancer cells, resulting in increased resistance to Fas receptor-mediated apoptosis by disturbing association between FADD (fas-associated death domain) and caspase 8.

Physical form

Supplied in 50 mM Sodium Phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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