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H3791

Anti-HOXA3 antibody produced in rabbit

~1.0 mL/mL, affinity isolated antibody

Synonym(s):

Anti-HOX1, Anti-HOX1E, Anti-Homeobox A3, Anti-MGC10155

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02263083
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
6
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biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~60 kDa

species reactivity

human, mouse

packaging

antibody small pack of 25 μL

concentration

~1.0 mL/mL

technique(s)

immunoprecipitation (IP): 5-10 μg using lysates of HEK-293T cells expressing human HOXA3, indirect immunofluorescence: 2-5 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human HOXA3, western blot: 2-4 μg/mL using lysates of HEK-293T cells over expressing human HOXA3

UniProt accession no.

O43365

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HOXA3(3200)
mouse ... Hoxa3(15400)

General description

Homeobox A3 (HOXA3) transcription factor/protein belongs to the HOX family. The HOXA3 gene is mapped on the human chromosome at 7p15.2.

Application

Anti-HOXA3 antibody produced in rabbit may be used in:
  • proximity ligation assay
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

Biochem/physiol Actions

Anti-HOXA3 specifically recognizes HOXA3.
Disruption of the homeobox A3 (HOXA3) gene results in embryonic lethality, which was rescued by placing HOXD3. HOXA3 gene expression is upregulated during neovascularization as a result of injury indicating that HOXA3 promotes angiogenesis. Mutations of the HOXA3 gene are associated with defects in thymus organogenesis and parathyroid development.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Preparation Note

Store at −20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze at −20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation. Discard working dilutions if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
低风险生物材料

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Certificates of Analysis (COA)

Lot/Batch Number
030M4758

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Related Content

Data Sheet - H3791

Instructions

D Su et al.
Developmental biology, 236(2), 316-329 (2001-07-31)
The thymus and parathyroid glands in mice develop from a thymus/parathyroid primordium that forms from the endoderm of the third pharyngeal pouch. We investigated the molecular mechanisms that promote this unique process in which two distinct organs form from a
Maria Fernanda Setúbal Destro Rodrigues et al.
Genomics, 108(5-6), 185-193 (2016-11-09)
Approximately 300 homeobox loci were identified in the euchromatic regions of the human genome, of which 235 are probable functional genes and 65 are likely pseudogenes. Many of these genes play important roles in embryonic development and cell differentiation. Dysregulation
J M Greer et al.
Nature, 403(6770), 661-665 (2000-02-25)
Biological diversity is driven mainly by gene duplication followed by mutation and selection. This divergence in either regulatory or protein-coding sequences can result in quite different biological functions for even closely related genes. This concept is exemplified by the mammalian
View All Related Papers

Global Trade Item Number

SKUGTIN
H3791-200UL04061838031297
H3791-25UL04061838031303