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H4001

Hydrocortisone

Name: Hydrocortisone
Brand: SIGMA

synthetic (organic), ≥98% (HPLC), anti-inflammatory agent, powder

Synonym(s):

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₃₀O₅

CAS Number:

50-23-7

Molecular Weight:

362.46

NACRES:

NA.77

PubChem Substance ID:

24278466

UNSPSC Code:

51111800

EC Number:

200-020-1

MDL number:

MFCD00011654

Beilstein/REAXYS Number:

1354819

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

300

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Properties

Product Name

Hydrocortisone, ≥98% (HPLC)

biological source

synthetic (organic)

Quality Level

300

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

mp

211-214 °C (lit.)

solubility

water: 0.28 g/L at 25 °C

application(s)

cell analysis

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

Gene Information

human ... ABCB1(5243), CYP3A4(1576), NR3C1(2908), SERPINA6(866)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)
rat ... Ar(24208), Nr3c1(24413)

Description

Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex.

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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pictograms

GHS08

signalword

Danger

hcodes

H360Df,H373

pcodes

P202 - P260 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1A - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

监管及禁止进口产品

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Increased cortisol awakening response was associated with time to recurrence of major depressive disorder.

Florian Hardeveld et al.

Psychoneuroendocrinology, 50, 62-71 (2014-09-03)

Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening

Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring.

Rachel Yehuda et al.

The American journal of psychiatry, 171(8), 872-880 (2014-05-17)

Differential effects of maternal and paternal posttraumatic stress disorder (PTSD) have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor sensitivity and vulnerability to psychiatric disorder. The authors examined the relative influences of maternal and paternal PTSD

Continuous subcutaneous hydrocortisone infusion versus oral hydrocortisone replacement for treatment of addison's disease: a randomized clinical trial.

Marianne Oksnes et al.

The Journal of clinical endocrinology and metabolism, 99(5), 1665-1674 (2014-02-13)

Conventional glucocorticoid replacement therapy fails to mimic the physiological cortisol rhythm, which may have implications for morbidity and mortality in patients with Addison's disease. The objective of the study was to compare the effects of continuous sc hydrocortisone infusion (CSHI)

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Global Trade Item Number

SKU	GTIN
H4001-100G	04061833794418
H4001-1G	04061833794432
H4001-25G	04061833794456
H4001-5G	04061833794463
H4001-10G	04061833794425