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H4413

Hydroxyfasudil hydrochloride hydrate

Name: Hydroxyfasudil hydrochloride hydrate
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₇N₃O₃S · HCl · xH₂O

CAS Number:

155558-32-0

Molecular Weight:

343.83 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

24724499

UNSPSC Code:

12352200

MDL number:

MFCD06411567

Assay:

≥98% (HPLC)

Form:

solid

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

composition

The two peaks show the equilibrim between the two tautomers

color

white

solubility

H₂O: >5 mg/mL

storage temp.

2-8°C

SMILES string

Cl[H].Oc1nccc2c(cccc12)S(=O)(=O)N3CCCNCC3

InChI

1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H

InChI key

XWWFOUVDVJGNNG-UHFFFAOYSA-N

Description

Application

Hydroxyfasudil hydrochloride hydrate has been used as a ROCK inhibitor to study the role of different signaling pathways in the chemokines CCL19 and CCL21, the CCR7 ligands mediated effects on migratory and prosurvival, in CLL cells.

Biochem/physiol Actions

Hydroxyfasudil possessantispastic action. It is an active metabolite of fasudil. Hydroxyfasudil might enhance the dynamics of blood flow and prevent damage caused by neutrophils.

Rho-kinase inhibitor.

Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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