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Merck
CN

H4413

Hydroxyfasudil hydrochloride hydrate

≥98% (HPLC), solid

Synonym(s):

1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C14H17N3O3S · HCl · xH2O
CAS Number:
155558-32-0
Molecular Weight:
343.83 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
24724499
UNSPSC Code:
12352200
MDL number:
MFCD06411567

Key Documents

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InChI key

XWWFOUVDVJGNNG-UHFFFAOYSA-N

SMILES string

Cl[H].Oc1nccc2c(cccc12)S(=O)(=O)N3CCCNCC3

InChI

1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H

assay

≥98% (HPLC)

form

solid

composition

The two peaks show the equilibrim between the two tautomers

color

white

solubility

H2O: >5 mg/mL

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

Hydroxyfasudil hydrochloride hydrate has been used as a ROCK inhibitor to study the role of different signaling pathways in the chemokines CCL19 and CCL21, the CCR7 ligands mediated effects on migratory and prosurvival, in CLL cells.

Biochem/physiol Actions

Hydroxyfasudil possessantispastic action. It is an active metabolite of fasudil. Hydroxyfasudil might enhance the dynamics of blood flow and prevent damage caused by neutrophils.
Rho-kinase inhibitor.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
119K4615V
0000077162
0000077163
0000036348
0000036349

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Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage
Satoh SI, et al.
Life Sciences, 69(12), 1441-1453 (2001)
Analysis of migratory and prosurvival pathways induced by the homeostatic chemokines CCL19 and CCL21 in B-cell chronic lymphocytic leukemia
Cuesta-Mateos C, et al.
Experimental Hematology, 38(9), 756-764 (2010)
Ghulam Mohammad et al.
Annals of clinical and laboratory science, 48(2), 137-145 (2018-04-22)
To investigate the effects of blocking Rho kinase pathway on the expression of inflammatory signaling pathways in the retina of diabetic mice and in human retinal Müller glial cells stimulated with high-glucose to replicate hyperglycemia. Retinas from diabetic mice and

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