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H4644

Hypercalcemia of malignancy factor 1-40 human

Name: Hypercalcemia of malignancy factor 1-40 human
Brand: SIGMA

≥95% (HPLC), suitable fo drug transporter assays

Synonym(s):

Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile-Arg-Ala-Thr-Ser, PTH-Like Adenylate Cyclase Stimulating Protein, PTHrP (1-40), Parathyroid hormone-related protein (1-40)

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About This Item

Empirical Formula (Hill Notation):

C₂₀₇H₃₃₄N₆₆O₅₈

CAS Number:

120298-73-9

Molecular Weight:

4675.27

UNSPSC Code:

12352201

NACRES:

NA.26

MDL number:

MFCD00081712

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Properties

Product Name

Hypercalcemia of malignancy factor 1-40 human, ≥95% (HPLC)

Quality Level

200

assay

≥95% (HPLC)

form

solid

technique(s)

drug transporter assay: suitable

UniProt accession no.

P12272

storage temp.

−20°C

Gene Information

human ... PTHLH(5744)

Description

Biochem/physiol Actions

Hypercalcemia of malignancy factor fragment 1-40 human is a parathyroid hormone-like protein (PLP) fragment used to study parathyroid hormone-related signaling pathways.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

0000490833

0000488464

0000471811

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Tumor necrosis factor enhances parathyroid hormone-related protein-induced hypercalcemia and bone resorption without inhibiting bone formation in vivo.

H L Uy et al.

Cancer research, 57(15), 3194-3199 (1997-08-01)

Humoral hypercalcemia of malignancy results from the effects of tumor-produced factors on bone, kidney, and intestine that disrupt normal calcium homeostasis. Although parathyroid hormone-related protein (PTHrP) is a major mediator of the syndrome, tumors also produce other hypercalcemic factors, such

Effects of transforming growth factor-alpha on parathyroid hormone- and parathyroid hormone-related protein-mediated bone resorption and adenylate cyclase stimulation in vitro.

T J Rosol et al.

Domestic animal endocrinology, 8(4), 499-507 (1991-10-01)

The effects of transforming growth factor-alpha (TGF alpha) were determined on the ability of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP) to stimulate bone resorption and adenylate cyclase in vitro. Bovine PTH-(1-34) and human PTHrP-(1-34) were equipotent in their

Parathyroid hormone-related peptide stimulates proliferation of highly tumorigenic human SV40-immortalized breast epithelial cells.

C Cataisson et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 15(11), 2129-2139 (2000-11-25)

Parathyroid hormone-related protein (PTHrP) is the main mediator of humoral hypercalcemia of malignancy (HHM) and it is produced by many tumors, including breast cancers. Breast epithelial cells as well as breast cancer tumors and cell lines have been reported as

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Global Trade Item Number

SKU	GTIN
H4644-.1MG	04061832820606