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H4884

Hippuryl-His-Leu acetate salt

Name: Hippuryl-His-Leu acetate salt
Brand: SIGMA

≥98% (HPLC), angiotensin converting enzyme substrate, powder

Synonym(s):

N-Benzoyl-Gly-His-Leu

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₇N₅O₅

CAS Number:

103404-54-2

Molecular Weight:

429.47

UNSPSC Code:

12352200

PubChem Substance ID:

329815212

NACRES:

NA.32

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Product Name

Hippuryl-His-Leu acetate salt,

assay

≥98% (HPLC)

Quality Level

200

form

powder

solubility

acetic acid: 50 mg/mL, clear, colorless to very faintly yellow

storage temp.

−20°C

SMILES string

CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)c2ccccc2)C(O)=O

InChI

1S/C21H27N5O5.C2H4O2/c1-13(2)8-17(21(30)31)26-20(29)16(9-15-10-22-12-24-15)25-18(27)11-23-19(28)14-6-4-3-5-7-14;1-2(3)4/h3-7,10,12-13,16-17H,8-9,11H2,1-2H3,(H,22,24)(H,23,28)(H,25,27)(H,26,29)(H,30,31);1H3,(H,3,4)/t16-,17-;/m0./s1

InChI key

NSEVQQKNHZCIKL-QJHJCNPRSA-N

Gene Information

human ... ACE(1636), ACE2(59272)
mouse ... ACE3(217246)
rat ... ACE(11421), ACE2(70008), ACE3(498012)

Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

Substrate for angiotensin converting enzyme.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Mammalian Genome null

Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins.

Lucas Actis-Goretta et al.

FEBS letters, 555(3), 597-600 (2003-12-17)

It was determined that flavan-3-ols and procyanidins have an inhibitory effect on angiotensin I converting enzyme (ACE) activity, and the effect was dependent on the number of epicatechin units forming the procyanidin. The inhibition by flavan-3-ols and procyanidins was competitive

Emblicanin rich Emblica officinalis extract encapsulated double emulsion: controlled release of bioactive during phagocytosis and in vitro digestion.

Neha Chaudhary et al.

Journal of food science and technology, 57(4), 1371-1381 (2020-03-18)

Controlled release of Emblicanin rich water soluble extract of Emblica officinalis (EEO) from the inner phase of water-in-oil-in-water type double emulsion (DE), during in vitro digestion and phagocytosis was investigated. It was observed that release of EEO (measured as total polyphenols

Differential ACE expression among tissues in allele-specific Wistar rat lines.

Jelena Kamilic et al.

Mammalian genome : official journal of the International Mammalian Genome Society, 20(3), 170-179 (2009-03-04)

In humans, the insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene accounts for half of the variance in plasma ACE activity. The deletion allele is associated with high plasma ACE activity, cardiovascular disease, and renal disease. In rat, a

Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor.

Matthew L Hemming et al.

The Journal of biological chemistry, 280(45), 37644-37650 (2005-09-13)

Human genetic data have associated angiotensin-converting enzyme (ACE) with Alzheimer disease (AD), and purified ACE has been reported to cleave synthetic amyloid beta-protein (Abeta) in vitro. Whether deficiency in ACE activity, arising from genetic alteration or pharmacological inhibition, can decrease

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Global Trade Item Number

SKU	GTIN
H4884-100MG	04061833796405
H4884-1G	04061833796412
H4884-500MG	04061833796467
H4884-25MG	04061833796450

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