H4914
Honokiol
≥98% (HPLC), Antiangeogenic reagent, powder
Synonym(s):
5,3′-Diallyl-2,4′-dihydroxybiphenyl, NSC 293100
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About This Item
Empirical Formula (Hill Notation):
C18H18O2
CAS Number:
Molecular Weight:
266.33
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Product Name
Honokiol, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
solubility
DMSO: 36 mg/mL
antibiotic activity spectrum
Gram-positive bacteria, neoplastics
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O
InChI
1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
InChI key
FVYXIJYOAGAUQK-UHFFFAOYSA-N
General description
Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.
Application
Honokiol has been used:
- to study its effects on plasmid hSirt3102-399 deacetylation activity
- as an antioxidant to study its cytoprotective role in human ovarian cancer cells (SKOV-3) and Chinese hamster ovary cells (CHOK1)
- to explore its effects on oxidative stress and mitochondrial dysfunction via a sirt3-dependent manner
- for intracerebroventricular (ICV) cannulation
Biochem/physiol Actions
Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 2 - Eye Dam. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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