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H5388

Hyaluronic acid sodium salt from rooster comb

Name: Hyaluronic acid sodium salt from rooster comb
Brand: SIGMA

avian glycosaminoglycan polysaccharide

Synonym(s):

Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating

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About This Item

CAS Number:

9067-32-7

UNSPSC Code:

12352201

PubChem Substance ID:

24895688

NACRES:

NA.25

MDL number:

MFCD01773053

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biological source

chicken (rooster comb)

Quality Level

200

form

powder

impurities

≤2% protein (Lowry)

color

white

solubility

water: ~5 g/L

cation traces

Na: 3-7%

storage temp.

−20°C

SMILES string

[Na+].N([C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(=O)O)O)CO)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO)O)NC(=O)C)C(=O)O)C(=O)C

InChI

1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1

InChI key

YWIVKILSMZOHHF-QJZPQSOGSA-N

Related Categories

Biochemicals

Carbohydrates for Biochemical Research

Cell Culture Supplements & Reagents

Chemical Biology

Application

Hyaluronic acid sodium salt from rooster comb has been used:

as a component of bi-layer gelatin scaffold
as a vehicle for release of gentamicin during left ear surgery in guinea pigs
in hyaluronic acid binding assay in human embryonic kidney cell line 293T

Biochem/physiol Actions

Hyaluronic acid is a polysaccharide present in the skin, connective tissue, vitreous humor and synovial fluid. It is essential for tissue hydration and functions to regenerate skin post injury or wounds. Hyaluronic acid, apart from having dermatologic and ophthalmologic applications, serves as a drug delivery vehicle. Hyaluronic acid also exhibits antioxidant and antiglycation properties.

High molecular mass polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine which forms the core of complex proteoglycan aggregates found in extracellular matrix.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Purification and characterization of hyaluronic acid from chicken combs

Rosa CS, et al.

Ciencia Rural, 42(9), 1682-1687 (2012)

Hyaluronan binding motifs of USP17 and SDS3 exhibit anti-tumor activity

Ramakrishna S, et al.

PLoS ONE, 7(5), e37772-e37772 (2012)

The effect of gelatin--chondroitin sulfate--hyaluronic acid skin substitute on wound healing in SCID mice

Wang TW, et al.

Biomaterials, 27(33) (2006)

Extraction, purification and characterization of hyaluronic acid from Rooster comb

Kulkarni SS, et al.

Journal of Applied and Natural Science, 10(1), 313-315 (2018)

Rheology and confocal reflectance microscopy as probes of mechanical properties and structure during collagen and collagen/hyaluronan self-assembly.

Ya-li Yang et al.

Biophysical journal, 96(4), 1566-1585 (2009-02-17)

In this work, the gelation of three-dimensional collagen and collagen/hyaluronan (HA) composites is studied by time sweep rheology and time lapse confocal reflectance microscopy (CRM). To investigate the complementary nature of these techniques, first collagen gel formation is investigated at

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Articles

Glycosaminoglycan Sulfation and Signaling

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Glycosaminoglycans and Proteoglycans

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

糖胺聚糖和蛋白多糖

有五种已发现的糖胺聚糖链（参见图1）透明质酸不是硫酸化的，但其他糖胺聚糖链在链的不同位置含有硫酸根取代基。

Pharmaceutical Research Applications of Carbohydrates and Polysaccharides

Discover the role of carbohydrates in drug delivery, from solubility and stability improvement to advanced controlled-release systems.

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Protocols

Enzymatic Assay of Hyaluronidase (3.2.1.35)

To measure hyaluronidase activity, a turbidimetric determination assay is used at 600 nm. One unit of hyaluronidase activity will cause a change in absorbance of 0.330 per minute at pH 5.35 at 37 °C.

透明质酸酶的酶法测定 (3.2.1.35)

在测定透明质酸酶活性时，使用了一种在600 nm处的比浊测定法进行测定。在pH 5.35、37 °C下，一单位的透明质酸酶活性可每分钟引起0.330的吸光值改变。

Global Trade Item Number

SKU	GTIN
H5388-100MG	04061833799369
H5388-1G	04061833799376
H5388-250MG	04061833799383

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