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H6161

[Gly¹⁴]-Humanin G human

Name: [Gly<SUP>14</SUP>]-Humanin G human
Brand: SIGMA

≥95% (HPLC), powder

Synonym(s):

S14G-humanin, HNG

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About This Item

UNSPSC Code:

12352209

NACRES:

NA.32

MDL number:

MFCD03787971

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biological source

human

Quality Level

200

assay

≥95% (HPLC)

form

powder

mol wt

2654.2-2660.2 Da

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

activity assay: suitable

solubility

water: 1.00-1.04 mg/mL, clear, colorless

shipped in

dry ice

storage temp.

−20°C

SMILES string

S(CC[C@H](N)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCC(=O)N[C@@H](

InChI

1S/C118H202N34O31S2/c1-19-65(14)92(112(179)144-81(54-90(159)160)104(171)145-82(52-63(10)11)114(181)152-46-29-37-86(152)109(176)148-91(64(12)13)111(178)139-72(32-23-24-41-119)97(164)137-74(35-27-44-129-118(125)126)98(165)136-73(34-26-43-128-117(123)124)96(

InChI key

WUYRHUFIUFJVQU-XJUNAYMOSA-N

General description

Research area: Neuroscience

[Gly14]-humanin (HNG) belongs to the family of mitochondrial-derived peptides. HNG (humanin-G) is an analog of humanin, generated by S14G (serine-14-glycine) mutation. HNG shows a 1000 times stronger activity.

Application

[Gly14]-Humanin G human has been used:

along with bortezomib in pharmacological inhibition studies to treat mice to limit the toxic effects of bortezomib
to study its effect on high glucose (HG)-induced apoptosis of endothelial cells (ECs)
to study its neuroprotective effects in an in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) model using SH-SY5Y neuroblastoma cells

[Gly¹⁴]-Humanin G human has been used to limit the toxicity during the bortezomib treatment in neonatal brachial plexus injury (NBPI) mice model. It has also been used in the cell culture of the human-derived neuroblastoma cell line.

Biochem/physiol Actions

Endogenous rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer′s disease genes and Aβ

Endogenous rescue factor abolishing neuronal cell death by many familial Alzheimer′s disease genes.

[Gly14]-humanin (HNG) stimulates cell growth, proliferation, and cell cycle progression. It enhances proteins such as kinases, transporters, transmembrane receptors, and transcription and translational regulators. HNG exhibits intense in vitro neuroprotective effects compared to natural HN. Studies show that it is an effective cytoprotectant both in vitro and in vivo. HNG is found to prevent high glucose (HG)-induced apoptosis of endothelial cells (ECs). It is proven to inhibit AngII-induced phenotypic switch in vascular smooth muscle cells (VSMCs).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Proteasome inhibition preserves longitudinal growth of denervated muscle and prevents neonatal neuromuscular contractures.

Sia Nikolaou et al.

JCI insight, 4(23) (2019-10-30)

Muscle contractures are a prominent and disabling feature of many neuromuscular disorders, including the 2 most common forms of childhood neurologic dysfunction: neonatal brachial plexus injury (NBPI) and cerebral palsy. There are currently no treatment strategies to directly alter the

Timing of proteasome inhibition as a pharmacologic strategy for prevention of muscle contractures in neonatal brachial plexus injury.

Qingnian Goh et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(2), e21214-e21214 (2020-11-26)

Neonatal brachial plexus injury (NBPI) causes disabling and incurable contractures, or limb stiffness, which result from proteasome-mediated protein degradation impairing the longitudinal growth of neonatally denervated muscles. We recently showed in a mouse model that the 20S proteasome inhibitor, bortezomib

Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury

Wang X, et al.

Biomedicine and Pharmacotherapy, 110 (2019)

S14G-Humanin ameliorates ovalbumin-induced airway inflammation in asthma mediated by inhibition of toll-like receptor 4 (TLR4) expression and the nuclear factor κ-B (NF-κB)/early growth response protein-1 (Egr-1) pathway.

Bo Su et al.

Aging, 15(14), 6822-6833 (2023-07-15)

Asthma is a chronic inflammatory disease with a high morbidity rate in children and significantly impacts their healthy growth. It is reported that Th2 cell-mediated airway inflammation and activated oxidative stress are involved in the pathogenesis of asthma. S14G-humanin (HNG)

Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury.

Xin Wang et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 110, 248-253 (2018-12-06)

Skin provides the protective barrier for our body and undergoes the continuous regeneration in order to overcome damage from exposure to harmful environments and wounds. Epidermal stem cells (ESCs) play critical roles in skin regeneration. Humanin analogue, S14G-humanin (HNG), a

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Global Trade Item Number

SKU	GTIN
H6161-500UG	04061833384923

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