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H6649

Herbimycin A from Streptomyces hygroscopicus

Name: Herbimycin A from <I>Streptomyces hygroscopicus</I>
Brand: SIGMA

≥95% (HPLC), powder

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About This Item

Empirical Formula (Hill Notation):

C₃₀H₄₂N₂O₉

CAS Number:

70563-58-5

Molecular Weight:

574.66

UNSPSC Code:

12352200

NACRES:

NA.77

PubChem Substance ID:

24895756

MDL number:

MFCD00151702

Beilstein/REAXYS Number:

4834067

Assay:

≥95% (HPLC)

Form:

powder

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Properties

biological source

Streptomyces hygroscopicus

Quality Segment

200

assay

≥95% (HPLC)

form

powder

color

yellow

solubility

DMSO: 7.5 mg/mL

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O

InChI

1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1

InChI key

MCAHMSDENAOJFZ-BVXDHVRPSA-N

Description

General description

DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.

Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic. It is an analog of geldanamycin.

Application

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells and rat intestinal epithelial cells. It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.

Biochem/physiol Actions

An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.

Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.

Disclaimer

Hygroscopic and photosensitive

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

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Global Trade Item Number

SKU	GTIN
H6649-1MG	04061826132074
H6649-.1MG	04061832448930