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H6904

6β-Hydroxycortisol

Name: 6&#946;-Hydroxycortisol
Brand: SIGMA

synthetic (organic), ≥98%, organic anion transporter 3 substrate, powder

Synonym(s):

4-Pregnene-6,11β,17,21-tetrol-3,20-dione

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₃₀O₆

CAS Number:

3078-34-0

Molecular Weight:

378.46

UNSPSC Code:

51111800

PubChem Substance ID:

24895777

NACRES:

NA.77

MDL number:

MFCD00200405

Assay:

≥98%

Form:

powder

Quality level:

200

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Properties

Product Name

6β-Hydroxycortisol, ≥98%

biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

assay

≥98%

form

powder

technique(s)

HPLC: suitable

solubility

methanol: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

CC12CCC(=O)C=C1C(O)CC3C4CC[C@](O)(C(=O)CO)C4(C)CC(O)C23

InChI

1S/C21H30O6/c1-19-5-3-11(23)7-14(19)15(24)8-12-13-4-6-21(27,17(26)10-22)20(13,2)9-16(25)18(12)19/h7,12-13,15-16,18,22,24-25,27H,3-6,8-10H2,1-2H3/t12?,13?,15?,16?,18?,19?,20?,21-/m0/s1

InChI key

GNFTWPCIRXSCQF-JFQOUMBGSA-N

Description

Application

6β-Hydroxycortisol has been used in liquid chromatography with tandem mass spectrometry (LC/MS/MS) analysis to confirm the human embryonic kidney (HEK293) cell-based conversion of parent cortisol to 6β-hydroxycortisol (6βOH) metabolites.

Biochem/physiol Actions

6β-Hydroxycortisol is a metabolite of cortisol.

6β-Hydroxycortisol serves as a substrate for the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins (MATE1 and MATE-2K).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease.

Kevin A Lidberg et al.

Scientific reports, 11(1), 4722-4722 (2021-02-27)

CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad spectrum of renal disorders. Pharmacogenetic studies have reported inconsistent linkages between CYP3A5 expression and hypertension, however, most investigators have

6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects.

Yuichiro Imamura et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(4), 685-694 (2014-02-04)

6β-Hydroxycortisol (6β-OHF) is a substrate of the organic anion transporter 3 (OAT3) and the multidrug and toxin extrusion proteins MATE1 and MATE-2K in the corresponding cDNA-transfected cells. This study aimed to examine the contribution of OAT3 and MATEs to the