H7403
Anti-Histamine antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti Histamine Antibody, Histamine Antibody, Histamine Antibody - Anti-Histamine antibody produced in rabbit
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
wide range
technique(s)
dot blot: 1:14,000 using histamine-BSA.
immunohistochemistry: 1:100 using 4% paraformaldehyde/4% carbodiimide-fixed or 4% paraformaldehyde-fixed sections of rat stomach
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Histamine, (2-(4-Imidazolyl)ethylamine), is a widely distributed substance in peripheral tissues. Histamine is localized in mast cells, neuronal cells and neuroendocrine cells of the gastric tract. It is also expressed in lungs, kidney, in cerebrovascular endothelial cells and throughout the peripheral nervous system.
Immunogen
histamine conjugated to succinylated KLH
Application
Anti-Histamine antibody produced in rabbit has been used:
- in immunohistochemistry
- to test immunohistochemical reactions of Pseudophoxinus antalyae digestive system tissues
- in immunocytochemical assays
- in immunofluorescence assays
Biochem/physiol Actions
Histamine, (2-(4-Imidazolyl)ethylamine) mediates a variety of physiological activities including inflammation, gastric acid secretion and smooth muscle contraction. It is also implicated in modulation of cell growth and differentiation, during embryogenesis, and tumor growth and in the suppression of mitogen-induced lymphocyte proliferation. In the central nervous system (CNS), histamine acts as a neurotransmitter/ neuromodulator of various brain activities.
The product specifically stains histamine-containing cells in paraformaldehyde/carbodiimide-fixed or paraformaldehyde-fixed, paraffin-embedded sections of rat stomach (endocrine cells and mast cells).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Immunohistochemical localization of cholecystokinin and histamine in gastrointestinal tract in flower fish
SENOL N, et al.
Experimental Physiology, 1(1), 26-34 (2006)
A Vodenicharov et al.
Anatomia, histologia, embryologia, 34(6), 343-349 (2005-11-18)
Morphological, morphometric, histochemical and immunocytochemical investigations on mast cells, located in the wall of ureter of 8 months aged pigs were performed. Mast cells were found in all three layers of ureteral wall, but their distribution was irregular and the
Histamine mediates osteoclastic resorption only during the acute phase of bone loss in ovariectomized rats
Lesclous Ph, et al.
Experimental Physiology, 91(3), 561-570 (2006)
The haemocytes of the colonial aplousobranch ascidian Diplosoma listerianum: Structural, cytochemical and functional analyses
Cima F, et al.
Micron (Oxford, England : 1993), 102, 51-64 (2017)
Jasmin Becker et al.
Frontiers in physiology, 10, 329-329 (2019-04-12)
The density of intestinal mast cells has been reported to increase during inflammatory bowel disease (IBD). As mast cell mediators are known to increase the permeability of epithelial tight junctions, we hypothesized that antigen responses in sensitized animals might be
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