H7654
Hydroxyguanidine sulfate salt
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About This Item
Linear Formula:
CH5N3O · 1/2H2SO4
CAS Number:
Molecular Weight:
124.11
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
228-749-0
MDL number:
InChI key
MTGDDPZRXSDPFH-UHFFFAOYSA-N
InChI
1S/2CH5N3O.H2O4S/c2*2-1(3)4-5;1-5(2,3)4/h2*5H,(H4,2,3,4);(H2,1,2,3,4)
SMILES string
NC(=N)NO.NC(=N)NO.OS(O)(=O)=O
biological source
synthetic (organic)
assay
≥98% (TLC)
form
powder
solubility
water: 25 mg/mL, clear, colorless
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
An early antitumor agent. Oxidation results in release of NO, and formation of other reactive oxygen species, including peroxynitrite and peroxyl radicals. Reacts with NO to form an adduct which is a potent and stable vasodilator.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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David Lefèvre-Groboillot et al.
The FEBS journal, 272(12), 3172-3183 (2005-06-16)
The binding of several alkyl- and aryl-guanidines and N-hydroxyguanidines to the oxygenase domain of inducible NO-synthase (iNOS(oxy)) was studied by UV/Vis difference spectroscopy. In a very general manner, monosubstituted guanidines exhibited affinities for iNOS(oxy) that were very close to those
Patrick Slama et al.
Biochemical and biophysical research communications, 316(4), 1081-1087 (2004-03-27)
Conversion of neurotransmitter dopamine into norepinephrine is catalyzed by dopamine beta-hydroxylase (DbH). The reaction requires the presence of both molecular oxygen and a reducing cosubstrate, the assumed physiological cosubstrate being ascorbic acid. We have investigated the ability of a new
Daniel Mansuy et al.
Free radical biology & medicine, 37(8), 1105-1121 (2004-09-29)
Nitric oxide (NO) is a key inter- and intracellular molecule involved in the maintenance of vascular tone, neuronal signaling, and host response to infection. The biosynthesis of NO in mammals involves a two-step oxidation of L-arginine (L-Arg) to citrulline and
Zhi-guo Zhang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 39(9), 705-710 (2004-12-21)
To search for novel antiasthmatic agents. Coupling seratrodast (SD), an antiasthmatic drug, with several different types of NO donors including oxatriazoles, N-hydroxyguanidines and furoxans; evaluating the antiasthmatic effects of coupled compounds by determining their inhibitory activity of guinea pig asthma
Patrick Slama et al.
Journal of inorganic biochemistry, 103(3), 455-462 (2009-01-31)
N-Aryl-N'-hydroxyguanidines are compounds that display interesting pharmacological properties but their chemical reactivity remains poorly investigated. Some of these compounds are substrates for the heme-containing enzymes nitric-oxide synthases (NOS) and act as reducing co-substrates for the copper-containing enzyme Dopamine beta-Hydroxylase (DBH)
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