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H7654

Hydroxyguanidine sulfate salt

Name: Hydroxyguanidine sulfate salt
Brand: SIGMA

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About This Item

Linear Formula:

CH₅N₃O · 1/2H₂SO₄

CAS Number:

6345-29-5

Molecular Weight:

124.11

NACRES:

NA.77

PubChem Substance ID:

329815245

UNSPSC Code:

12352202

EC Number:

228-749-0

MDL number:

MFCD00042033

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Properties

biological source

synthetic (organic)

assay

≥98% (TLC)

form

powder

solubility

water: 25 mg/mL, clear, colorless

storage temp.

2-8°C

SMILES string

NC(=N)NO.NC(=N)NO.OS(O)(=O)=O

InChI

1S/2CH5N3O.H2O4S/c2*2-1(3)4-5;1-5(2,3)4/h2*5H,(H4,2,3,4);(H2,1,2,3,4)

InChI key

MTGDDPZRXSDPFH-UHFFFAOYSA-N

Description

Biochem/physiol Actions

An early antitumor agent. Oxidation results in release of NO, and formation of other reactive oxygen species, including peroxynitrite and peroxyl radicals. Reacts with NO to form an adduct which is a potent and stable vasodilator.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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N-hydroxyguanidines as substrates of nitric oxide synthases.

T Bill Cai et al.

Current topics in medicinal chemistry, 5(7), 721-736 (2005-08-17)

Nitric oxide (NO) has been implicated in a wide variety of disease states. Both inhibitors and substrates of nitric oxide synthase (NOS) could have great therapeutic potential in the treatment of these diseases. There is considerable pharmacological interest in developing

1-(2-Mercaptobenzenesulfonyl)-3-hydroxyguanidines--novel potent antiproliferatives, synthesis and in vitro biological activity.

Kamil Brożewicz et al.

European journal of medicinal chemistry, 55, 384-394 (2012-08-16)

Twenty four 1-[2-alkylthio-5-(azol-2 or 5-yl)-4-chlorobenzenesulfonyl]-3-hydroxyguanidines 6a-x have been synthesized in order to evaluate their biological activity. Compounds 6a, 6c, 6d, 6f, 6g, 6i-p, 6r-t, and 6v-x were tested for their in vitro anticancer activity at the US National Cancer Institute. The

Zembowicz, A., et al.

British Journal of Pharmacology, 107, 1007-1007 (1992)

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Global Trade Item Number

SKU	GTIN
H7654-50MG	04061832947884