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H7666

IL-12 human

HumanKine®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

Synonym(s):

Interleukin-12 human, IL-12

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00212975
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized
Mol wt:
dimer 57 kDa (glycosylated)
Impurities:
endotoxin, tested
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Product Name

Interleukin-12 human, HumanKine®, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin, tested

biological source

human

Quality Level

200

recombinant

expressed in HEK 293 cells

assay

≥95% (SDS-PAGE)

form

lyophilized

potency

≤2 ng/mL EC50

mol wt

dimer 57 kDa (glycosylated)

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

storage temp.

−20°C

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Application

Interleukin-12 (IL-12) human has been used to study IL-12 mediated enhancement of IL-12Rβ2 (IL-12 receptor) expression.

Biochem/physiol Actions

Interleukin-12 (IL-12) was identified as a factor secreted by human Epstein-Barr (EBV)-transformed B cell lines. IL-12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL-12 is produced predominantly by monocytes and NK cells and induces T cells and NK cells to produce IFN-γ. Human IL-12 is not active on mouse cells, but murine IL-12 is active on both murine and human lymphocytes. The biological activity of recombinant human IL-12 was measured by its ability to stimulate the proliferation of PHA-activated human T lymphoblasts. IL-12 has anti-angiogenic properties.

Physical form

lyophilized from a 0.2 μm filtered solution of PBS

Analysis Note

The specific activity was determined by the dose-dependent release of IFN-γ from the human NK92 cell line in presence of 20 ng/mL rIL-2.

Legal Information

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
0000504195
0000504195
0000375951
0000350826
0000350826

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T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease.
Matsuoka K et al.
Gut, 53, 1303-1303 (2004)

Global Trade Item Number

SKUGTIN
H7666-10UG04061833804315

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